ArticleCellular and molecular neurobiology2014
Antioxidant and neuroprotective activities of Hyptis suaveolens (L.) Poit. against oxidative stress-induced neurotoxicity.
Article in Cellular and molecular neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
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- Influence of Hyptis suaveolens growth stage on essential oil composition, antimicrobial and antioxidant activities.Scientific reports · 2025Article
- Alpha-amylase and Alpha-glucosidase enzymes inhibition and antioxidant potential of selected medicinal plants used as anti-diabetes by Sundanese community in West Java, Indonesia.BMC complementary medicine and therapies · 2025Article
- Antioxidant Effects of Quercetin Nanocrystals in Nanosuspension against Hydrogen Peroxide-Induced Oxidative Stress in a Zebrafish Model.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Black Pepper (Antioxidants (Basel, Switzerland) · 2023Article
- Traditional Uses, Phytochemistry, and Bioactivities ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Chemical Composition, Antioxidant, and Mosquito Larvicidal Activity of Essential Oils fromJournal of experimental pharmacology · 2022Article
- Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide-Induced Apoptotic Toxicity.Pharmaceuticals (Basel, Switzerland) · 2021Article
- A review on the phytochemical and pharmacological properties ofFuture journal of pharmaceutical sciences · 2021Review
- Artemisia amygdalina Upregulates Nrf2 and Protects Neurons Against Oxidative Stress in Alzheimer Disease.Cellular and molecular neurobiology · 2019Article
- Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria.TheScientificWorldJournal · 2018Article
- The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Study on Chemical Profile and Neuroprotective Activity of Myrica rubra Leaf Extract.Molecules (Basel, Switzerland) · 2017Article
- Alpha-Amylase Inhibition and Antioxidative Capacity of Some Antidiabetic Plants Used by the Traditional Healers in Southeastern Nigeria.TheScientificWorldJournal · 2017Article
- Evaluation of antioxidant and cytoprotective activities of Artemisia ciniformis extracts on PC12 cells.Iranian journal of basic medical sciences · 2016Article
- Protective effects of Arctium lappa L. roots against hydrogen peroxide-induced cell injury and potential mechanisms in SH-SY5Y cells.Cellular and molecular neurobiology · 2015Article
- Cytotoxic effects of oosporein isolated from endophytic fungus Cochliobolus kusanoi.Frontiers in microbiology · 2015Article
- Neuroprotective effects of bikaverin on H2O2-induced oxidative stress mediated neuronal damage in SH-SY5Y cell line.Cellular and molecular neurobiology · 2014Article
- Antioxidant and Nephroprotective Activities of the Extract and Fractions ofPharmacognosy magazineArticle
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5 authors at 1 institution in 1 country.
Funding
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Abstract
The present study was carried out to investigate the antioxidant and neuroprotective effects of Hyptis suaveolens methanol extract (HSME) using various in vitro systems. The total phenol and flavonoids contents of the HSME were quantified by colorimetric methods. The HSME extract exhibited potent antioxidant activity as determined by 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, 2,2-diphenyl-1-picrylhydrazyl, and ferric reducing antioxidant power assays. The neuroprotective activity of HSME was determined on mouse N2A neuroblastoma cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, lactate dehydrogenase, intracellular ROS assays, and upregulation of brain neuronal markers at genetic level. The N2A cells were pretreated with different concentrations (0.5, 1, 1.5, and 2 mg/ml) of the extract and then exposed to H2O2 to induce oxidative stress and neurotoxicity. The survival of the cells treated with different concentrations of HSME and H2O2 increased as compared to cells exposed only to H2O2 (47.3 %) (p < 0.05). The HSME also dose-dependently reduced LDH leakage and intracellular ROS production (p < 0.05). Pretreatment with HSME promotes the upregulation of tyrosine hydroxylase (2.41-fold, p < 0.05), and brain-derived neurotrophic factor genes (2.15-fold, p < 0.05) against H2O2-induced cytotoxicity in N2A cells. Moreover, the HSME showed antioxidant activity and decreased neurotoxicity. These observations suggest that HSME have marked antioxidant and neuroprotective activities.
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