ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2014
New science challenges old notion that mercury dental amalgam is safe.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Human Mercury Biomonitoring Under the Minamata Convention: Blood, Urine, Hair, and Tissue Biomarkers (2000-2026).Biological trace element research · 2026Review
- Heavy Metal Toxicity in Clinical and Environmental Health: Sources, Mechanisms, Diagnostics, and Evidence-Based Management of Mercury, Lead, Cadmium, and Arsenic.International journal of molecular sciences · 2026Review
- Human biomonitoring in support of the Minamata Convention: a case of phasing out dental amalgam.Environmental health : a global access science source · 2026Article
- Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria.The American journal of medicine · 2025Review
- Association Between Genotoxic Effects of Ageing Dental Restorations and Micronuclei in Oral Mucosal Cells.Medicina (Kaunas, Lithuania) · 2025Article
- Mercury Concentration in Saliva and the Impact of Chewing: An Inductively Coupled Plasma Mass Spectrometry Study.Biological trace element research · 2024Article
- Assessment of Cytotoxic and Genotoxic Effect of Modern Dental MaterialsActa stomatologica Croatica · 2023Article
- Adult Mesenchymal Stem Cells from Oral Cavity and Surrounding Areas: Types and Biomedical Applications.Pharmaceutics · 2023Review
- Mercury and Parkinson's Disease: Promising Leads, but Research Is Needed.Parkinson's disease · 2023Review
- Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut-Brain Axis.Microorganisms · 2022Review
- Review
- Natural and Conventional Cosmetics-Mercury Exposure Assessment.Molecules (Basel, Switzerland) · 2021Article
- Mercury and Alzheimer's disease: a look at the links and evidence.Metabolic brain disease · 2021Review
- Dental Amalgams and the Incidence Rate of Arthritis among American Adults.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2021Article
- Reported asthma and dental amalgam exposure among adults in the United States: An assessment of the National Health and Nutrition Examination Survey.SAGE open medicine · 2021Article
- Seafood, wine, rice, vegetables, and other food items associated with mercury biomarkers among seafood and non-seafood consumers: NHANES 2011-2012.Journal of exposure science & environmental epidemiology · 2020Article
- Knowledge and Attitude of Dentists and Patients Toward Use and Health Safety of Dental Amalgam in Saudi Arabia.European journal of dentistry · 2020Article
- [Mercury exposure and dentists' health status in two regions of centrall Morocco: descriptive cross-sectional survey].The Pan African medical journal · 2020Article
- Insights into the Potential Role of Mercury in Alzheimer's Disease.Journal of molecular neuroscience : MN · 2019Review
- Rethinking the Dental Amalgam Dilemma: An Integrated Toxicological Approach.International journal of environmental research and public health · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mercury dental amalgam has a long history of ostensibly safe use despite its continuous release of mercury vapor. Two key studies known as the Children's Amalgam Trials are widely cited as evidence of safety. However, four recent reanalyses of one of these trials now suggest harm, particularly to boys with common genetic variants. These and other studies suggest that susceptibility to mercury toxicity differs among individuals based on multiple genes, not all of which have been identified. These studies further suggest that the levels of exposure to mercury vapor from dental amalgams may be unsafe for certain subpopulations. Moreover, a simple comparison of typical exposures versus regulatory safety standards suggests that many people receive unsafe exposures. Chronic mercury toxicity is especially insidious because symptoms are variable and nonspecific, diagnostic tests are often misunderstood, and treatments are speculative at best. Throughout the world, efforts are underway to phase down or eliminate the use of mercury dental amalgam.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.