Evidence map›Paper›PMID 24419526›Full record

ArticleBone marrow transplantation2014

NHANES III equations enhance early detection and mortality prediction of bronchiolitis obliterans syndrome after hematopoietic SCT.

K M Williams, O Hnatiuk, S A Mitchell, K Baird, S M Gadalla, S M Steinberg, J Shelhamer, A Carpenter, D Avila, T Taylor and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00656058 (Multi-Institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans Following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00656058 phase2completednot on this map

Multi-Institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans Following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2008 to 2018Enrolled25ConditionsBronchiolitis Obliterans, Chronic Graft Versus Host Disease, Leukotriene, MontelukastArmsSingulair (Montelukast Sodium)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

K M Williams1] Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA [2] Division of Blood and Marrow Transplantation, Center for Cancer and Blood Disorders, Children's National Medical Center, The George Washington University Medical Center, Washington, DC, USA.
O HnatiukPulmonary, Critical Care and Sleep Medicine Service, Raymond G. Murphy VA Medical Center, Albuquerque, NM, USA.
S A MitchellDivision of Cancer Control and Population Sciences, Outcomes Research Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
K BairdPediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
S M GadallaClinical Genetics Branch, DCEG, NCI, Bethesda, MD, USA.
S M SteinbergBiostatistics and Data Management Section, OCD, CCR, NCI, NIH, Bethesda, MD, USA.
J ShelhamerCritical Care Medicine Department, NIH, Bethesda, MD, USA.
A CarpenterExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
D AvilaExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
T TaylorExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
L GrkovicDivision of Hematology, Department of Internal Medicine, Clinical Hospital Center Zagreb, Zagreb, Croatia.
D PulanicDivision of Hematology, Department of Internal Medicine, Clinical Hospital Center Zagreb, Zagreb, Croatia.
L E ComisRehabilitation Medicine, NIH, Bethesda, MD, USA.
B Blacklock-SchuverExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
R E GressExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
S Z PavleticExperimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

Funding

ETIB Clinical TrialsZIABC010960 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRESS, RONALD · 2009 to 2023
$30.7M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Bronchiolitis obliterans syndrome (BOS) is a serious complication of chronic GVHD (cGVHD) following HSCT (hematopoietic SCT). The clinical diagnosis of BOS is based on pulmonary function test (PFT) abnormalities including: FEV1<75% predicted and obstructive FEV1/VC ratio, calculated using reference equations. We sought to determine if the frequency of clinical diagnoses and severity of BOS would be altered by using the recommended NHANES III vs older equations (Morris/Goldman/Bates, MGB) in 166 cGVHD patients, median age 48 (range: 12-67). We found that NHANES III equations significantly increased the prevalence of BOS, with an additional 11% (18/166) meeting diagnostic criteria by revealing low FEV1 (<75%) (P<0.0001), and six additional patients by obstructive ratio (vs MBG). Collectively, this led to an increase of BOS incidence from 17 (29/166) to 29% (41/166). For patients with severe BOS, (FEV1<35%), NHANES III equations correctly predicted death 71.4% vs 50% using MGB. In conclusion, the use of NHANES III equations markedly increases the proportion of cases meeting diagnostic criteria for BOS and improves prediction of survival.

Indexed as

AdolescentAdultAgedBronchiolitis ObliteransChildChronic DiseaseCohort StudiesCross-Sectional StudiesEarly DiagnosisFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedRespiratory Function Tests

Identifiers

PMID24419526
PMCPMC5562366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.