Evidence map›Paper›PMID 24419516›Full record

ArticleBone marrow transplantation2014

Ethnicity, length of time on the register and sex predict donor availability at the confirmatory typing stage.

R N Lown, S G E Marsh, G E Switzer, K A Latham, J A Madrigal, B E Shaw

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. How perceptions of bone marrow donation costs affect donation behavior: survey evidence from a large donor registry.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R N Lown1] Anthony Nolan Research Institute, Royal Free Hospital, London, UK [2] UCL Cancer Institute, University College London, London, UK.
S G E Marsh1] Anthony Nolan Research Institute, Royal Free Hospital, London, UK [2] UCL Cancer Institute, University College London, London, UK.
G E Switzer1] Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA [2] Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA [3] Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA [4] Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, USA.
K A LathamAnthony Nolan Research Institute, Royal Free Hospital, London, UK.
J A Madrigal1] Anthony Nolan Research Institute, Royal Free Hospital, London, UK [2] UCL Cancer Institute, University College London, London, UK.
B E Shaw1] Anthony Nolan Research Institute, Royal Free Hospital, London, UK [2] UCL Cancer Institute, University College London, London, UK [3] Royal Marsden NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite over 20 million unrelated donors being listed worldwide, donor attrition at the confirmatory typing (CT) stage of donor acquisition is a key source of delay. Anthony Nolan undertook a study of CT requests from 2010 to 2011 to identify factors associated with attrition. Of 7541 CT requests, 38.2% were cancelled for donor reasons. Of these, 19.4% were personal, 34.1% medical, 36% no contact, 7.9% emigrated and 2.6% others. African (odds ratio (OR) 2.78, P<0.001), African-Caribbean (OR 3.07, P<0.001), Asian (OR 2.65, P<0.001), Jewish (OR 1.54, P=0.009) and Mediterranean (OR=2.38, P<0.001) donors were more likely not to be available compared to Caucasian donors. Female donors were also more likely not to be available (OR=1.32, P<0.001): primarily due to pregnancy. Older donors were less likely to be available in univariate analysis, but this association was not significant after controlling for other factors. Blood donors and those recruited within the past five years had lower rates of attrition. Accumulation of additional attrition-associated characteristics for a given donor was associated with progressively greater odds of attrition (OR 1.99, 2.52, 3.4 and 5.53, respectively, for 1, 2, 3 and 4 risk factors, P<0.001). Donor registries must develop evidence-driven strategies to recruit and retain the most reliable donors.

Indexed as

AdolescentAdultAge FactorsEthnicityFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedPregnancyRegistriesRisk FactorsSex FactorsTransplantation, HomologousUnrelated DonorsYoung Adult

Identifiers

PMID24419516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.