ArticleActa crystallographica. Section D, Biological crystallography2014
Structural basis for the broad specificity of a new family of amino-acid racemases.
Article in Acta crystallographica. Section D, Biological crystallography, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Ornithine racemase uses a catalytic cysteine.Biochimica et biophysica acta. Proteins and proteomics · 2026Article
- Identification and characterization of RacX, a new broad-specificity amino acid racemase from a novel taxon within the orderApplied and environmental microbiology · 2026Article
- DIVERGE v4: A Platform for Large-Scale Analysis of Functional Divergence Across Multi-Gene Families.Molecular biology and evolution · 2025Article
- Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria.Journal of molecular evolution · 2025Article
- A prototrophic suppressor of aJournal of bacteriology · 2024Article
- A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria.Nature communications · 2024Article
- Review
- D-amino acids involved in stress-induced response in Vibrio cholerae.Nature microbiology · 2023Article
- D-amino acids signal a stress-dependent run-away response in Vibrio cholerae.Nature microbiology · 2023Article
- Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase fromACS bio & med chem Au · 2023Article
- Promising applications of D-amino acids in periprosthetic joint infection.Bone research · 2023Review
- Vancomycin Resistance inMicroorganisms · 2022Review
- The Conserved Family of the Pyridoxal Phosphate-Binding Protein (PLPBP) and Its Cyanobacterial Paradigm PipY.Life (Basel, Switzerland) · 2022Review
- Identification and biochemical characterization of threonine dehydratase from the hyperthermophile Thermotoga maritima.Amino acids · 2021Article
- Binding of non-canonical peptidoglycan controlsComputational and structural biotechnology journal · 2021Article
- Molecular mechanisms of vancomycin resistance.Protein science : a publication of the Protein Society · 2020Review
- Transition of the Bacterial Community and Culturable Chitinolytic Bacteria in Chitin-treated Upland Soil: From Streptomyces to Methionine-auxotrophic Lysobacter and Other Genera.Microbes and environments · 2020Article
- d-amino Acids in Health and Disease: A Focus on Cancer.Nutrients · 2019Review
- Knockout of alanine racemase gene attenuates the pathogenicity of Aeromonas hydrophila.BMC microbiology · 2019Article
- Biochemical Characterization of theFrontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
Broad-spectrum amino-acid racemases (Bsrs) enable bacteria to generate noncanonical D-amino acids, the roles of which in microbial physiology, including the modulation of cell-wall structure and the dissolution of biofilms, are just beginning to be appreciated. Here, extensive crystallographic, mutational, biochemical and bioinformatic studies were used to define the molecular features of the racemase BsrV that enable this enzyme to accommodate more diverse substrates than the related PLP-dependent alanine racemases. Conserved residues were identified that distinguish BsrV and a newly defined family of broad-spectrum racemases from alanine racemases, and these residues were found to be key mediators of the multispecificity of BrsV. Finally, the structural analysis of an additional Bsr that was identified in the bioinformatic analysis confirmed that the distinguishing features of BrsV are conserved among Bsr family members.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.