Evidence map›Paper›PMID 24419360›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2014

Multivitamin mineral supplementation in patients with chronic fatigue syndrome.

Daniela Maric, Snezana Brkic, Slavica Tomic, Aleksandra Novakov Mikic, Tatjana Cebovic, Vesna Turkulov

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2017
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Management of chronic fatigue syndrome/myalgic encephalomyelitis in a pediatric population: A scoping review.Journal of child health care : for professionals working with children in the hospital and community · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome.International journal of clinical and experimental medicine · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniela MaricClinic for Infectious Diseases, Clinical Center Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Snezana BrkicClinic for Infectious Diseases, Clinical Center Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Slavica TomicClinic for Infectious Diseases, Clinical Center Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Aleksandra Novakov MikicFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Tatjana CebovicBiochemistry Department, Clinical Center Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Vesna TurkulovClinic for Infectious Diseases, Clinical Center Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
University of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic fatigue syndrome (CFS) is characterized by medically unexplained persistent or reoccurring fatigue lasting at least 6 months. CFS has a multifactorial pathogenesis in which oxidative stress (OS) plays a prominent role. Treatment is with a vitamin and mineral supplement, but this therapeutic option so far has not been properly researched. MATERIAL AND

methodsThis prospective study included 38 women of reproductive age consecutively diagnosed by CDC definition of CFS and treated with a multivitamin mineral supplement. Before and after the 2-month supplementation, SOD activity was determined and patients self-assessed their improvement in 2 questionnaires: the Fibro Fatigue Scale (FFS) and the Quality of Life Scale (SF36). Results There was a significant improvement in SOD activity levels; and significant decreases in fatigue (p=0.0009), sleep disorders (p=0.008), autonomic nervous system symptoms (p=0.018), frequency and intensity of headaches (p=0.0001), and subjective feeling of infection (p=0.0002). No positive effect on quality of life was found.

conclusionsTreatment with a vitamin and mineral supplement could be a safe and easy way to improve symptoms and quality of life in patients with CFS.

Indexed as

Enzyme-Linked Immunosorbent AssayFatigue Syndrome, ChronicFemaleHumansOxidative StressProspective StudiesQuality of LifeSerbiaSuperoxide DismutaseSurveys and QuestionnairesTrace ElementsVitaminsSuperoxide DismutaseTrace ElementsVitamins

Identifiers

PMID24419360
PMCPMC3907507
OpenAlexW2097315819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.