ArticleAntimicrobial agents and chemotherapy2014
Identification of a novel membrane transporter mediating resistance to organic arsenic in Campylobacter jejuni.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Arsenic efflux mechanisms in ectomycorrhizal mushrooms Hebeloma bulbiferum and Hebeloma sinapizans.Applied microbiology and biotechnology · 2026Article
- A reduction-secretion system contributes to roxarsone (V) degradation and efflux in Brevundimonas sp. M20.BMC microbiology · 2025Article
- Living to the High Extreme: Unraveling the Composition, Structure, and Functional Insights of Bacterial Communities Thriving in the Arsenic-Rich Salar de Huasco Altiplanic Ecosystem.Microbiology spectrum · 2021Article
- Recent advances in exploring the heavy metal(loid) resistant microbiome.Computational and structural biotechnology journal · 2021Review
- Expansion of the Transporter-Opsin-G protein-coupled receptor superfamily with five new protein families.PloS one · 2020Article
- Genomic Variation and Arsenic Tolerance Emerged as Niche Specific Adaptations by DifferentFrontiers in microbiology · 2020Article
- Pathways of arsenic uptake and efflux.Environment international · 2019Review
- Genetic mechanisms of arsenic detoxification and metabolism in bacteria.Current genetics · 2019Review
- Efflux Transporter ArsK Is Responsible for Bacterial Resistance to Arsenite, Antimonite, Trivalent Roxarsone, and Methylarsenite.Applied and environmental microbiology · 2018Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Integrative Conjugative Element ICEFrontiers in veterinary science · 2018Article
- Distribution of Arsenic Resistance Genes in Prokaryotes.Frontiers in microbiology · 2018Review
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- The organoarsenical biocycle and the primordial antibiotic methylarsenite.Metallomics : integrated biometal science · 2016Review
- Transformation and characterization of an arsenic gene operon from urease-positive thermophilic Campylobacter (UPTC) in Escherichia coli.Folia microbiologica · 2016Article
- ArsP: a methylarsenite efflux permease.Molecular microbiology · 2015Article
- The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Clinical microbiology reviews · 2015Review
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Although bacterial mechanisms involved in the resistance to inorganic arsenic are well understood, the molecular basis for organic arsenic resistance has not been described. Campylobacter jejuni, a major food-borne pathogen causing gastroenteritis in humans, is highly prevalent in poultry and is reportedly resistant to the arsenic compound roxarsone (4-hydroxy-3-nitrobenzenearsonic acid), which has been used as a feed additive in the poultry industry for growth promotion. In this study, we report the identification of a novel membrane transporter (named ArsP) that contributes to organic arsenic resistance in Campylobacter. ArsP is predicted to be a membrane permease containing eight transmembrane helices, distinct from other known arsenic transporters. Analysis of multiple C. jejuni isolates from various animal species revealed that the presence of an intact arsP gene is associated with elevated resistance to roxarsone. In addition, inactivation of arsP in C. jejuni resulted in 4- and 8-fold reductions in the MICs of roxarsone and nitarsone, respectively, compared to that for the wild-type strain. Furthermore, cloning of arsP into a C. jejuni strain lacking a functional arsP gene led to 16- and 64-fold increases in the MICs of roxarsone and nitarsone, respectively. Neither mutation nor overexpression of arsP affected the MICs of inorganic arsenic, including arsenite and arsenate, in Campylobacter. Moreover, acquisition of arsP in NCTC 11168 led to accumulation of less roxarsone than the wild-type strain lacking arsP. Together, these results indicate that ArsP functions as an efflux transporter specific for extrusion of organic arsenic and contributes to the resistance to these compounds in C. jejuni.
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