ArticleScientific reports2014
Electrical stimulation enhances cell migration and integrative repair in the meniscus.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
35 citing papers in PubMed, 101 citations in OpenAlex.
- In vitro electrical stimulation devices: practical framework for design, fabrication, and operation.Journal of biological engineering · 2026Article
- Engineering 3D-printed standalone conductive nerve guides using soft bioinks for peripheral nerve injuries.Materials advances · 2026Article
- Effects of mechanical and electrical stimulation on accelerating greenstick fracture Healing: Insights from finite element analysis and experimental validation.Journal of orthopaedics · 2025Article
- Electrical stimulation directs articular chondrocyte and chondrosarcoma migration in a 3D collagen matrix.Biochemical and biophysical research communications · 2025Article
- Review
- Engineering 3D Scaffold-Free Nanoparticle-Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A bioelectronic device for electric field treatment of wounds reduces inflammation in an in vivo mouse model.PloS one · 2024Article
- Article
- Electrical Stimulation in Cartilage Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023Review
- Electroactive Spinal Instrumentation for Targeted Osteogenesis and Spine Fusion: A Computational Study.International journal of spine surgery · 2023Article
- 3D printable conductive composite inks for the fabrication of biocompatible electrodes in tissue engineering application.International journal of bioprinting · 2023Review
- Recent advances of responsive scaffolds in bone tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Impediments to Meniscal Repair: Factors at Play Beyond Vascularity.Frontiers in bioengineering and biotechnology · 2022Article
- Mesenchymal Stem Cells From Different Sources in Meniscus Repair and Regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- Current Development in Interdigital Transducer (IDT) Surface Acoustic Wave Devices for Live Cell In Vitro Studies: A Review.Micromachines · 2021Review
- Electrically Conductive and 3D-Printable Oxidized Alginate-Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering.Advanced healthcare materials · 2021Article
- Vascular endothelial and smooth muscle cell galvanotactic response and differential migratory behavior.Experimental cell research · 2021Article
- Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering.Stem cells international · 2021Review
- Cyclic Strain and Electrical Co-stimulation Improve Neural Differentiation of Marrow-Derived Mesenchymal Stem Cells.Frontiers in cell and developmental biology · 2021Article
- Identification of pathways and genes associated with meniscus degeneration using bioinformatics analyses.American journal of translational research · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Electrical signals have been applied towards the repair of articular tissues in the laboratory and clinical settings for over seventy years. We focus on healing of the meniscus, a tissue essential to knee function with limited innate repair potential, which has been largely unexplored in the context of electrical stimulation. Here we demonstrate for the first time that electrical stimulation enhances meniscus cell migration and integrative tissue repair. We optimize pulsatile direct current electrical stimulation parameters on cells at the micro-scale, and apply these to healing of full-thickness defects in explants at the macro-scale. We report increased expression of the adenosine A2b receptor in meniscus cells after stimulation at the micro- and macro-scale, and propose a role for A2bR in meniscus electrotransduction. Taken together, these findings advance our understanding of the effects of electrical signals and their mechanisms of action, and contribute to developing electrotherapeutic strategies for meniscus repair.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.