Evidence map›Paper›PMID 24419039›Full record

ArticleMolecular psychiatry2014

Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder.

I Shalev, T E Moffitt, A W Braithwaite, A Danese, N I Fleming, S Goldman-Mellor, H L Harrington, R M Houts, S Israel, R Poulton and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 4 syntheses or guidelines pooled it, 158 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Depression and telomere length: A meta-analysis.Journal of affective disorders · 2016
    Pooled it
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Leukocyte telomere length is not shortened in methamphetamine dependence or methamphetamine-induced psychosis but is increased following traumatic events.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
    Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

I Shalev1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA.
T E Moffitt1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA [3] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA [4] Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK.
A W Braithwaite1] Department of Pathology, School of Medicine, University of Otago, Dunedin, New Zealand [2] Children's Medical Research Institute, University of Sydney, Wentworthville, NSW, Australia.
A Danese1] Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, London, UK.
N I FlemingDepartment of Pathology, School of Medicine, University of Otago, Dunedin, New Zealand.
S Goldman-Mellor1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA.
H L Harrington1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA.
R M Houts1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA.
S Israel1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA.
R PoultonDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
S P RobertsonDepartment of Paediatrics and Child Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
K Sugden1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA [3] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA [4] Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK.
B Williams1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA [3] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA [4] Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK.
A Caspi1] Department of Psychology and Neuroscience, Duke University, Durham, NC, USA [2] Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA [3] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA [4] Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK.
University of Otago · NZ

Funding

Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Science CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI James Moody · 2015 to 2026
$5.7M
Duke Population Research InstituteR24HD065563 · NICHD · DUKE UNIVERSITY · PI SANDERS, SETH G · 2010 to 2014
$1.4M
Generating new knowledge to support reversibility interventionsR01AG048895 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2014 to 2015
$311k
Medical Research Council MR/K00381XMedical Research Council MR/K00381X/1NIA NIH HHS AG032282NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG048895NICHD NIH HHS P2C HD065563NICHD NIH HHS R24 HD065563
6 · The paper itself

Abstract

There is evidence that persistent psychiatric disorders lead to age-related disease and premature mortality. Telomere length has emerged as a promising biomarker in studies that test the hypothesis that internalizing psychiatric disorders are associated with accumulating cellular damage. We tested the association between the persistence of internalizing disorders (depression, generalized anxiety disorder and post-traumatic stress disorder) and leukocyte telomere length (LTL) in the prospective longitudinal Dunedin Study (n=1037). Analyses showed that the persistence of internalizing disorders across repeated assessments from ages 11 to 38 years predicted shorter LTL at age 38 years in a dose-response manner, specifically in men (β=-0.137, 95% confidence interval (CI): -0.232, -0.042, P=0.005). This association was not accounted for by alternative explanatory factors, including childhood maltreatment, tobacco smoking, substance dependence, psychiatric medication use, poor physical health or low socioeconomic status. Additional analyses using DNA from blood collected at two time points (ages 26 and 38 years) showed that LTL erosion was accelerated among men who were diagnosed with internalizing disorder in the interim (β=-0.111, 95% CI: -0.184, -0.037, P=0.003). No significant associations were found among women in any analysis, highlighting potential sex differences in internalizing-related telomere biology. These findings point to a potential mechanism linking internalizing disorders to accelerated biological aging in the first half of the life course, particularly in men. Because internalizing disorders are treatable, the findings suggest the hypothesis that treating psychiatric disorders in the first half of the life course may reduce the population burden of age-related disease and extend health expectancy.

Indexed as

AdolescentAdultAgingAnxiety DisordersChildDepressive DisorderFemaleHumansLeukocytesLongitudinal StudiesMaleProspective StudiesSex CharacteristicsStress Disorders, Post-TraumaticTelomereYoung Adult

Identifiers

PMID24419039
PMCPMC4098012
OpenAlexW2062172666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.