ArticleThe Pediatric infectious disease journal2014
Clinical and laboratory factors that predict death in very low birth weight infants presenting with late-onset sepsis.
Article in The Pediatric infectious disease journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Trial
- Risk assessment of early-onset sepsis in extremely preterm infants: implications for antibiotic stewardship.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Pathogen Profiles and Antimicrobial Resistance Patterns of Neonatal Sepsis in the Gulf Cooperation Council: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Efficacy of Platelet Transfusion in Thrombocytopenia Due to Gram-Negative Late-Onset Neonatal Sepsis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Outcome prediction for late-onset sepsis after premature birth.Pediatric research · 2025Article
- Predictors of mortality and severe illness from Escherichia coli sepsis in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Variation in antibiotic consumption in very preterm infants-a 10 year population-based study.The Journal of antimicrobial chemotherapy · 2024Article
- Association Between Hypoglycemia and the Occurrence of Early Onset Sepsis in Premature Infants.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Late-onset sepsis in very preterm infants in Norway in 2009-2018: a population-based study.Archives of disease in childhood. Fetal and neonatal edition · 2023Article
- Development and validation of a rabbit model ofFrontiers in cellular and infection microbiology · 2023Article
- Peripheral platelet phagocytosis in an extremely low birth weight infant:a case report.Fukushima journal of medical science · 2022Article
- Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms.Journal of clinical medicine · 2022Article
- Risk Factors for Mortality From Late-Onset Sepsis Among Preterm Very-Low-Birthweight Infants: A Single-Center Cohort Study From Singapore.Frontiers in pediatrics · 2021Article
- Factors associated with the risk of positive blood culture in neonatal foals presented to a referral center (2000-2014).Journal of veterinary internal medicine · 2020Article
- Evaluation of factors for poor outcome in preterm newborns with posthemorrhagic hydrocephalus associated with late-onset neonatal sepsis.Therapeutics and clinical risk management · 2018Article
- Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.American journal of perinatology · 2017Article
- Article
- Pathogen-specific mortality in very low birth weight infants with primary bloodstream infection.PloS one · 2017Article
- Impact of healthcare-associated sepsis on mortality in critically ill infants.European journal of pediatrics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLate-onset sepsis (LOS) in very low birth weight (VLBW) infants is associated with significant morbidity and mortality. The ability to predict mortality in infants with LOS based on clinical and laboratory factors at presentation of illness remains limited.
objectivesTo identify predictors of sepsis-associated mortality from a composite risk profile that includes demographic data, category of infecting organism, clinical and laboratory data at onset of illness. STUDY
designData were collected from VLBW infants with at least 1 episode of LOS admitted to Yale Neonatal Intensive Care Unit from 1989 through 2007. Episodes were categorized as Gram-positive, Gram-negative or fungal. Multivariate logistic regression analysis was used to compare and contrast different types of infections and to assess independent risk factors for death.
resultsFour hundred twenty-four cases of LOS were identified in 424 VLBW infants. Of these, 262 (62%) were categorized as Gram-positive, 126 (30%) as Gram-negative and 36 (8%) as fungal. Multivariate analyses revealed that infants with Gram-positive infections had significantly lower odds of death compared to those with Gram-negative (adjusted odds ratio: 0.17; 95% confidence interval: 0.08-0.36) or fungal LOS (adjusted odds ratio: 0.22; 95% confidence interval: 0.07-0.64). Need for intubation, initiation of pressors, hypoglycemia and thrombocytopenia as presenting laboratory signs of infection and necrotizing enterocolitis were independent risk factors for sepsis-related death.
conclusionsWe identified presenting clinical and laboratory factors, including category of infecting organism, which predict the increased risk of LOS-related death. This information can be useful in estimating prognosis shortly after the onset of disease.
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