ArticleGenome biology and evolution2014
The diversity of prokaryotic DDE transposases of the mutator superfamily, insertion specificity, and association with conjugation machineries.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- New Insights inAntibiotics (Basel, Switzerland) · 2025Article
- Pan-immune system, mobilome and resistome inMicrobial genomics · 2025Article
- Mobile genetic elements in shapingFrontiers in microbiology · 2025Review
- Mobilome impacts on physiology in the widely used non-toxic mutant Microcystis aeruginosa PCC 7806 ΔmcyB and toxic wildtype.BMC genomics · 2024Article
- Independent evolution of transposase and TIRs facilitated by recombination betweenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Insertion sequence contributes to the evolution and environmental adaptation of Acidithiobacillus.BMC genomics · 2023Article
- Genomic investigation of the emergence ofAccess microbiology · 2023Article
- In silico prediction of the enzymes involved in the degradation of the herbicide molinate by Gulosibacter molinativorax ON4Scientific reports · 2022Article
- Genome Plasticity by Insertion Sequences Learned From a Case of Radiation-Resistant BacteriumBioinformatics and biology insights · 2021Article
- Article
- Genomic Islands in Mycoplasmas.Genes · 2020Review
- Genomics of Atlantic ForestMicrobial genomics · 2020Article
- Transposition of Insertion Sequences was Triggered by Oxidative Stress in Radiation-Resistant BacteriumMicroorganisms · 2019Article
- Giant Transposons in Eukaryotes: Is Bigger Better?Genome biology and evolution · 2019Review
- High Prevalence of Integrative and Conjugative Elements Encoding Transcription Activator-Like Effector Repeats inFrontiers in microbiology · 2019Article
- The Integrative Conjugative Element (ICE) ofmBio · 2018Article
- Review
- Integrative and conjugative elements and their hosts: composition, distribution and organization.Nucleic acids research · 2017Article
- Genome Stability in Engineered Strains of the Extremely Thermophilic Lignocellulose-Degrading Bacterium Caldicellulosiruptor bescii.Applied and environmental microbiology · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements (TEs) are major components of both prokaryotic and eukaryotic genomes and play a significant role in their evolution. In this study, we have identified new prokaryotic DDE transposase families related to the eukaryotic Mutator-like transposases. These genes were retrieved by cascade PSI-Blast using as initial query the transposase of the streptococcal integrative and conjugative element (ICE) TnGBS2. By combining secondary structure predictions and protein sequence alignments, we predicted the DDE catalytic triad and the DNA-binding domain recognizing the terminal inverted repeats. Furthermore, we systematically characterized the organization and the insertion specificity of the TEs relying on these prokaryotic Mutator-like transposases (p-MULT) for their mobility. Strikingly, two distant TE families target their integration upstream σA dependent promoters. This allowed us to identify a transposase sequence signature associated with this unique insertion specificity and to show that the dissymmetry between the two inverted repeats is responsible for the orientation of the insertion. Surprisingly, while DDE transposases are generally associated with small and simple transposons such as insertion sequences (ISs), p-MULT encoding TEs show an unprecedented diversity with several families of IS, transposons, and ICEs ranging in size from 1.1 to 52 kb.
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