Evidence map›Paper›PMID 24418538›Full record

ArticleVirology2014

The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation.

Jeanette I Webster Marketon, Jacqueline Corry, Michael N Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  8. [Effect of atopy on serum glucocorticoid receptor levels in children with bronchiolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jeanette I Webster MarketonDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, United States; Institute for Behavioral Medicine Research, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, United States. Electronic address: jeanette.marketon@gmail.com.
Jacqueline CorryDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, United States. Electronic address: Jacqueline.corry@nationwidechildrens.org.
Michael N TengJoy McCann Culverhouse Airway Disease Research Center, Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, United States.
The Ohio State University Wexner Medical Center · USUniversity of South Florida · US

Funding

Akt as a therapeutic target for respiratory syncytial virusR01AI081977 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI TENG, MICHAEL N · 2009 to 2012
$1.2M
NIAID NIH HHS R01 AI081977NIAID NIH HHS R01AI081977
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV)-induced bronchiolitis in infants is not responsive to glucocorticoids. We have shown that RSV infection impairs glucocorticoid receptor (GR) function. In this study, we have investigated the mechanism by which RSV impairs GR function. We have shown that RSV repression of GR-induced transactivation is not mediated through a soluble autocrine factor. Knock-down of mitochondrial antiviral signaling protein (MAVS), but not retinoic acid-inducible gene 1 (RIG-I) or myeloid differentiation primary response gene 88 (MyD88), impairs GR-mediated gene activation even in mock-infected cells. Over-expression of the RSV nonstructural protein NS1, but not NS2, impairs glucocorticoid-induced transactivation and viruses deleted in NS1 and/or NS2 are unable to repress glucocorticoid-induction of the known GR regulated gene glucocorticoid-inducible leucine zipper (GILZ). These data suggest that the RSV nonstructural proteins mediate RSV repression of GR-induced transactivation and that inhibition of the nonstructural proteins may be a viable target for therapy against RSV-related disease.

Indexed as

Transcriptional ActivationAdaptor Proteins, Signal TransducingDEAD Box Protein 58DEAD-box RNA HelicasesDown-RegulationGlucocorticoidsHumansReceptors, GlucocorticoidReceptors, ImmunologicRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsViral Nonstructural ProteinsAdaptor Proteins, Signal TransducingDEAD Box Protein 58DEAD-box RNA HelicasesGlucocorticoidsMAVS protein, humanNS2 protein, human respiratory syncytial virusReceptors, GlucocorticoidReceptors, ImmunologicRIGI protein, humanViral Nonstructural ProteinsGene regulationGlucocorticoidNonstructural proteinsRespiratory syncytial virus

Identifiers

PMID24418538
PMCPMC3904736
OpenAlexW2010291418

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.