Evidence map›Paper›PMID 24418527›Full record

ReviewChemistry and physics of lipids2014

The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast.

Susan A Henry, Maria L Gaspar, Stephen A Jesch

Open access · hybridAbstract readReview
In one paragraph

Review in Chemistry and physics of lipids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
  2. The Inner Nuclear Membrane Has a Unique Lipid Signature.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Inositol in Disease and Development: Roles of Catabolism viaInternational journal of molecular sciences · 2023
    Article
  13. The Lipid Profile of theJournal of fungi (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Susan A HenryDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. Electronic address: sah42@cornell.edu.
Maria L GasparDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Stephen A JeschDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Cornell University · US

Funding

GENETICS AND DEVELOPMENT OF YEAST MEMBRANE MUTANTSR01GM019629 · NIGMS · YESHIVA UNIVERSITY · PI HENRY, SUSAN ARMSTRONG · 1985 to 2015
$6.0M
GENETIC REGULATION OF PHOSPHOLIPID SYNTHESIS IN YEASTR37GM019629 · NIGMS · CORNELL UNIVERSITY ITHACA · PI HENRY, SUSAN A. · 1991 to 2000
$426k
STRUCTURE/FUNCTION ANALYSIS OF PHA4 IN C ELEGANSF32GM019629 · NIGMS · UNIVERSITY OF UTAH · PI KALTENBACH, LINDA S · 1999 to 2001
$59k
NIGMS NIH HHS F32 GM019629NIGMS NIH HHS GM-19629NIGMS NIH HHS R01 GM019629NIGMS NIH HHS R37 GM019629
6 · The paper itself

Abstract

This article focuses on discoveries of the mechanisms governing the regulation of glycerolipid metabolism and stress response signaling in response to the phospholipid precursor, inositol. The regulation of glycerolipid lipid metabolism in yeast in response to inositol is highly complex, but increasingly well understood, and the roles of individual lipids in stress response are also increasingly well characterized. Discoveries that have emerged over several decades of genetic, molecular and biochemical analyses of metabolic, regulatory and signaling responses of yeast cells, both mutant and wild type, to the availability of the phospholipid precursor, inositol are discussed.

Indexed as

Lipid MetabolismStress, PhysiologicalGlycerolHumansInositolMutationSaccharomyces cerevisiaeGlycerolInositolGlycerolipidsInositolPhosphatidic acidPhosphatidylinositolSphingolipidsStress response

Identifiers

PMID24418527
PMCPMC3980031
OpenAlexW2019928802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.