ArticleNeuroImage2014
Layer-dependent BOLD and CBV-weighted fMRI responses in the rat olfactory bulb.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- TMagnetic resonance in medicine · 2026Article
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- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
- Machine Learning-Based Clustering of Layer-Resolved fMRI Activation and Functional Connectivity Within the Primary Somatosensory Cortex in Nonhuman Primates.Human brain mapping · 2025Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Awake rodent fMRI: Gradient-echo echo planar imaging versus compressed-sensing fast low-angle shot.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Differential functional change in olfactory bulb and olfactory eloquent areas in Parkinson's disease.Brain communications · 2024Article
- Functional MRI of murine olfactory bulbs at 15.2T reveals characteristic activation patters when stimulated by different odors.Scientific reports · 2023Article
- Article
- Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex.Human brain mapping · 2023Article
- A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease.Seminars in cell & developmental biology · 2022Review
- Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T.Frontiers in neuroscience · 2021Article
- Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models.NeuroImage · 2019Review
- Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRNeuroImage · 2019Review
- Article
- Functional MRI of the mouse olfactory system.Neuroscience letters · 2019Article
- Mesoscopic and microscopic imaging of sensory responses in the same animal.Nature communications · 2019Article
- Effects of nicotine on odor-induced increases in regional blood flow in the olfactory bulb in rats.The journal of physiological sciences : JPS · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The olfactory bulb is a laminarized brain structure involved in odor sensation that has important implications to basic neuroscience research, like mechanisms for neurovascular coupling and early disease diagnosis. To investigate laminar-dependent responses to odor exposure, blood oxygenation level-dependent (BOLD) and cerebral blood volume weighted (CBVw) fMRI with iron oxide nanoparticle contrast agent were obtained with 110×110×500μm(3) resolution in urethane-anesthetized rats at 9.4T. The baseline total CBV is the largest at the olfactory bulb surface and midline, and decreases in the deeper layers, while a band of increased microvasculature density is observed at the glomerular, external plexiform and mitral cell layers. With odor exposure, CBVw fMRI is more sensitive and reproducible than BOLD. BOLD fMRI had the greatest activation on the bulb surface, midline, olfactory nerve and glomerular layers, while CBVw activation peaked in glomerular and external plexiform layers, but was still significant in mitral cell layer. Negative BOLD responses were observed in the bulb midline and near large blood vessels. CBVw laminar profiles are similar to the layer-dependent metabolic changes to the same odor exposure reported by previous glucose metabolism studies. Unique activation patterns for two different odor conditions were also differentiated with CBVw fMRI. Our study suggests that CBVw activation better represents the spatial location of metabolic activity in the olfactory bulb than BOLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.