Evidence map›Paper›PMID 24418351›Full record

Trial reportJournal of diabetes and its complications

Restorative yoga and metabolic risk factors: the Practicing Restorative Yoga vs. Stretching for the Metabolic Syndrome (PRYSMS) randomized trial.

Alka M Kanaya, Maria Rosario G Araneta, Sarah B Pawlowsky, Elizabeth Barrett-Connor, Deborah Grady, Eric Vittinghoff, Michael Schembri, Ann Chang, Mary Lou Carrion-Petersen, Traci Coggins and 3 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes and its complications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 11 pooled it
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 11 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  9. Metabolic syndrome and quality of life: a systematic review.Revista latino-americana de enfermagem · 2016
    Pooled it
  10. Use of Salivary Diurnal Cortisol as an Outcome Measure in Randomised Controlled Trials: a Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016
    Pooled it
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  17. Significance of Yoga for the Management of Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025
    Review
  18. Article
  19. Article
  20. MicroRNAs Associated With Incident Diabetes in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Alka M KanayaUniversity of California, San Francisco. Electronic address: alka.kanaya@ucsf.edu.
Maria Rosario G AranetaUniversity of California, San Diego.
Sarah B PawlowskyUniversity of California, San Francisco.
Elizabeth Barrett-ConnorUniversity of California, San Diego.
Deborah GradyUniversity of California, San Francisco.
Eric VittinghoffUniversity of California, San Francisco.
Michael SchembriUniversity of California, San Francisco.
Ann ChangUniversity of California, San Francisco.
Mary Lou Carrion-PetersenUniversity of California, San Diego.
Traci CogginsUniversity of California, San Francisco.
Daniah TanoriUniversity of California, San Diego.
Jean M ArmasUniversity of California, San Francisco.
Roger J ColeSynchrony Applied Health Sciences, Del Mar, CA.
University of California, San Francisco · USUniversity of California, San Diego · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) studyR01AT004569 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2009 to 2012
$2.1M
NCATS NIH HHS UL1 TR000004NCCIH NIH HHS 5R01AT004569NCCIH NIH HHS R01 AT004569NCRR NIH HHS UL1 RR024131
6 · The paper itself

Abstract

aimsIntensive lifestyle change prevents type 2 diabetes but is difficult to sustain. Preliminary evidence suggests that yoga may improve metabolic factors. We tested a restorative yoga intervention vs. active stretching for metabolic outcomes.

methodsIn 2009-2012, we conducted a 48-week randomized trial comparing restorative yoga vs. stretching among underactive adults with the metabolic syndrome at the Universities of California, San Francisco and San Diego. We provided lifestyle counseling and a tapering series of 90-min group classes in the 24-week intervention period and 24-week maintenance period. Fasting and 2-h glucose, HbA1c, triglycerides, HDL-cholesterol, insulin, systolic blood pressure, visceral fat, and quality of life were assessed at baseline, 6- and 12-months.

results180 participants were randomized and 135 (75%) completed the trial. At 12 months, fasting glucose decreased more in the yoga group than in the stretching group (-0.35 mmol/L vs. -0.03 mmol/L; p=0.002); there were no other significant differences between groups. At 6 months favorable changes within the yoga group included reductions in fasting glucose, insulin, and HbA1c and an increase in HDL-cholesterol that were not sustained at 1 year except changes in fasting glucose. The stretching group had a significant reduction in triglycerides at 6 months which was not sustained at 1 year but had improved quality of life at both time-points.

conclusionsRestorative yoga was marginally better than stretching for improving fasting glucose but not other metabolic factors.

Indexed as

Muscle Stretching ExercisesYogaAdultAgedBlood GlucoseDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansInsulinLife StyleLongitudinal StudiesMaleMetabolic SyndromeMiddle AgedTime FactorsBlood GlucoseGlycated HemoglobinInsulinTriglyceridesDiabetesPreventionRandomized clinical trialWeight management

Identifiers

PMID24418351
PMCPMC4004660
OpenAlexW2082104161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.