ArticleHeart rhythm2014
Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Heart rhythm, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
What it found
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Genetic and epigenetic landscape of non-familial sudden cardiac death.Molecular biology reports · 2026Review
- Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation.International journal of molecular sciences · 2022Article
- Article
- Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits.Circulation. Genomic and precision medicine · 2020Article
- Intake of Red and Processed Meat, Use of Non-Steroid Anti-Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish "Diet, Cancer and Health" Cohort.International journal of molecular sciences · 2019Article
- Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest.Galen medical journal · 2018Article
- A Common Variant in SCN5A and the Risk of Ventricular Fibrillation Caused by First ST-Segment Elevation Myocardial Infarction.PloS one · 2017Article
- Genetic variations involved in sudden cardiac death and their associations and interactions.Heart failure reviews · 2016Review
- Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest.Journal of nutritional science · 2016Article
Corrections and comments
- Erratum issuedSotoodhenia, Nona [corrected to Sotoodehnia, Nona]
Authors and funding
40 authors at 20 institutions in 7 countries.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington. Electronic address: rozenl@uw.edu.
Catherine O JohnsonCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Stephanie HesselsonCardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, California.
Nona Sotoodehnia
Nona SotoodheniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, Washington.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Thomas D ReaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Irena B KingDepartment of Medicine, University of New Mexico, Albuquerque, New Mexico.
Pui-Yan KwokCardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, California.
Angel MakCardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, California.
Guo LiCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Jennifer BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Eric LarsonGroup Health Research Institute, Seattle, Washington.
Dariush MozaffarianDepartment of Epidemiology, Harvard University, Boston, Massachusetts; Divisions of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington; Health Services, University of Washington, Seattle, Washington; Group Health Research Institute, Seattle, Washington.
Adriana Huertas-VazquezCedars-Sinai Medical Center, Heart Institute, Los Angeles, California.
Jean-Claude TardifMontreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
Christine M AlbertDivisions of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Stefan KääbDepartment of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University and Munich Heart Alliance, Munich, Germany.
Heikki V HuikuriInstitute of Clinical Medicine, Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Bouwe P KrijtheDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Aging [NCHA], The Netherlands.
Mark EijgelsheimDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Ying A WangNovartis Institutes for BioMedical Research, Cambridge, Massachusetts.
Kyndaron ReinierCedars-Sinai Medical Center, Heart Institute, Los Angeles, California.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Sara L PulitDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, the Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts.
Ramon BrugadaCardiovascular Genetics Center, Institut Investigació Biomèdica de Girona IDIBGI-Universitat de Girona, Girona, Spain.
Martina Müller-NurasyidDepartment of Medicine I, University Hospital Grosshadern, and Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Chris H Newton-ChehCenter for Human Genetic Research and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts.
Pekka J KarhunenDepartment of Forensic Medicine, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Aging [NCHA], The Netherlands; Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Inspectorate for Health Care, The Hague, The Netherlands.
Philippe GoyetteMontreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Torrance, California; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Sumeet S ChughCedars-Sinai Medical Center, Heart Institute, Los Angeles, California.
Aravinda ChakravartiMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Xavier JouvenDepartment of Cardiology, University Paris Descartes, Paris, France; Department of Epidemiology, University Paris Descartes, Paris, France.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington.
University of Washington · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USTampere University · FIUniversity of California, San Francisco · USErasmus MC · NLJohns Hopkins University · USBoston Biomedical Research Institute · USDélégation Paris 5 · FRDutch Health Care Inspectorate · NLHarbor–UCLA Medical Center · USHelmholtz Zentrum München · DEKaiser Permanente Washington Health Research Institute · USLudwig-Maximilians-Universität München · DEMassachusetts General Hospital · USMontreal Heart Institute · CAUniversité de Montréal · CAUniversity of Girona · ESUniversity of New Mexico · USUniversity of Oulu · FI
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MPhysicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MRISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8MDietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6MPRE-DETERMINE: Biologic Markers and MRI SCD Cohort StudyR01HL091069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALBERT, CHRISTINE M · 2008 to 2020
$12.9MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MJHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7MNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS CA-34944NCI NIH HHS CA 40360NCI NIH HHS CA55075NCI NIH HHS CA-87969NCI NIH HHS CA 97193NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1RR033176NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL-068070NHLBI NIH HHS HL080295NHLBI NIH HHS HL-080467NHLBI NIH HHS HL087652NHLBI NIH HHS HL-092111NHLBI NIH HHS HL105756NHLBI NIH HHS HL-26490NHLBI NIH HHS HL-34594NHLBI NIH HHS HL-34595NHLBI NIH HHS HL-35464NHLBI NIH HHS HL-46959NHLBI NIH HHS N01 HC-15103NHLBI NIH HHS N01‐HC‐25195NHLBI NIH HHS N01-HC-35129NHLBI NIH HHS N01-HC-45133NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85080NHLBI NIH HHS N01-HC-85081NHLBI NIH HHS N01-HC-85082NHLBI NIH HHS N01-HC-85083NHLBI NIH HHS N01-HC-85084NHLBI NIH HHS N01-HC-85085NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N01-HC-85239NHLBI NIH HHS N02‐HL‐6‐4278NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL088416NHLBI NIH HHS R01 HL088416-03S1NHLBI NIH HHS R01 HL088456NHLBI NIH HHS R01-HL088456NHLBI NIH HHS R01 HL091069NHLBI NIH HHS R01 HL091244NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01-HL092111NHLBI NIH HHS R01 HL092144NHLBI NIH HHS R01 HL105170-01NHLBI NIH HHS R01HL59367NIAMS NIH HHS T32 AR007175NIA NIH HHS AG-023629NIA NIH HHS AG-027058NIA NIH HHS AG-15928NIA NIH HHS AG-20098NIDDK NIH HHS DK063491NIDDK NIH HHS K23 DK65978NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079637NIDDK NIH HHS R01 DK078616
Abstract
backgroundThere is limited information on genetic factors associated with sudden cardiac arrest (SCA).
objectiveTo assess the association of common variation in genes in fatty acid pathways with SCA risk.
methodsWe selected 85 candidate genes and 1155 single nucleotide polymorphisms (SNPs) tagging common variation in each gene. We investigated the SNP associations with SCA in a population-based case-control study. Cases (n = 2160) were from a repository of SCA in the greater Seattle area. Controls (n = 2615), frequency-matched on age and sex, were from the same area. We used linear logistic regression to examine SNP associations with SCA. We performed permutation-based p-min tests to account for multiple comparisons within each gene. The SNP associations with a corrected P value of <.05 were then examined in a meta-analysis of these SNP associations in 9 replication studies totaling 2129 SCA cases and 23,833 noncases.
resultsEight SNPs in or near 8 genes were associated with SCA risk in the discovery study, one of which was nominally significant in the replication phase (rs7737692, minor allele frequency 36%, near the LPCAT1 gene). For each copy of the minor allele, rs7737692 was associated with 13% lower SCA risk (95% confidence interval -21% to -5%) in the discovery phase and 9% lower SCA risk (95% confidence interval -16% to -1%) in the replication phase.
conclusionsWhile none of the associations reached significance with Bonferroni correction, a common genetic variant near LPCAT1, a gene involved in the remodeling of phospholipids, was nominally associated with incident SCA risk. Further study is needed to validate this observation.
Indexed as
Death, Sudden, CardiacGenetic Predisposition to Disease1-Acylglycerophosphocholine O-AcyltransferaseAgedAlgorithmsAllelesCase-Control StudiesFatty AcidsFemaleGenetic VariationGenotypeHumansMalePolymorphism, Single NucleotideRisk Factors1-Acylglycerophosphocholine O-AcyltransferaseFatty AcidsLpcat1 protein, humanDeathGenetic epidemiologySudden
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