Evidence map›Paper›PMID 24417943›Full record

ReviewBest practice & research. Clinical endocrinology & metabolism2014

Regulation of adiponectin multimerization, signaling and function.

Meilian Liu, Feng Liu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Best practice & research. Clinical endocrinology & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. The role of adiponectin in Alzheimer's disease: A translational review.The journal of nutrition, health & aging · 2024
    Pooled it
  2. Pooled it
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  11. Observational
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  17. Adiponectin rescues synaptic plasticity in the dentate gyrus of a mouse model of Fragile X Syndrome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  18. Article
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Meilian LiuDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Second Xiangya Hospital, Metabolic Syndrome Research Center and Diabetes Center, Institute of Aging and Geriatric Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan, China. Electronic address: lium2@uthscsa.edu.
Feng LiuDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Second Xiangya Hospital, Metabolic Syndrome Research Center and Diabetes Center, Institute of Aging and Geriatric Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan, China. Electronic address: liuf@uthscsa.edu.
Second Xiangya Hospital of Central South University · CNThe University of Texas Health Science Center at San Antonio · US

Funding

Regulation and Function of Adiponectin OligomerizationR01DK076902 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LIU, FENG · 2008 to 2017
$2.9M
NIDDK NIH HHS R01 DK076902
6 · The paper itself

Abstract

Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and anti-diabetic functions. Different adiponectin complexes exert tissue-specific biological functions and activate distinct signaling pathways. In this review, we summarize our current understanding on the mechanisms regulating adiponectin multimerization. We also describe the major target tissues in which distinct adiponectin multimers exert their functional roles. Finally, we discuss the potential involvement of endoplasmic reticulum stress and mitochondrial stress in diet-induced adiponectin downregulation and highlight the roles of Disulfide bond A oxidoreductase-like protein (DsbA-L) in the prevention of endoplasmic reticulum stress and promotion of adiponectin multimerization, stability, and function.

Indexed as

Protein MultimerizationAdiponectinAMP-Activated Protein KinasesAnimalsCentral Nervous SystemEndoplasmic Reticulum StressGlutathione TransferaseHumansLiverMiceMuscle, SkeletalProtein StabilitySignal TransductionAdiponectinAMP-Activated Protein KinasesGlutathione TransferaseGSTK1 protein, humanadiponectinadiponectin multimerizationadiponectin multimersDsbA-LER stress

Identifiers

PMID24417943
PMCPMC3893790
OpenAlexW2025528312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.