Evidence map›Paper›PMID 24417601›Full record

Trial reportJournal of consulting and clinical psychology2014

Predictors and moderators of treatment response in childhood anxiety disorders: results from the CAMS trial.

Scott N Compton, Tara S Peris, Daniel Almirall, Boris Birmaher, Joel Sherrill, Phillip C Kendall, John S March, Elizabeth A Gosch, Golda S Ginsburg, Moira A Rynn and 9 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of consulting and clinical psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00052078 (Child/Adolescent Anxiety Multimodal Treatment Study), which is not on this map. Cited by 105 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 3 pooled it
29.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00052078 phase3completednot on this map

Child/Adolescent Anxiety Multimodal Treatment Study

TypeinterventionalSponsorJohns Hopkins UniversityRan2003 to 2008Enrolled488ConditionsAnxiety Disorders, Social Phobia, Generalized Anxiety DisorderArmsSertraline (SRT), Cognitive Behavioral Therapy (CBT), Placebo
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Pooled it
  2. The use of medication in selective mutism: a systematic review.European child & adolescent psychiatry · 2016
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  9. Acute Neurofunctional Effects of Escitalopram in Pediatric Anxiety: A Double-Blind, Placebo-Controlled Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2021
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 2 countries.

Scott N ComptonDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center.
Tara S PerisSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
Daniel AlmirallSurvey Research Center, Institute for Social Research, University of Michigan.
Boris BirmaherWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center.
Joel SherrillDivision of Services and Intervention Research, National Institute of Mental Health.
Phillip C KendallDepartment of Psychology, Temple University.
John S MarchDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center.
Elizabeth A GoschDepartment of Psychology, Philadelphia College of Osteopathic Medicine.
Golda S GinsburgDivision of Child and Adolescent Psychiatry, The Johns Hopkins Hospital.
Moira A RynnDepartment of Child Psychiatry, Columbia University Medical Center.
John C PiacentiniJohn C. Piacentini and James T. McCracken, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
James T McCrackenJohn C. Piacentini and James T. McCracken, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
Courtney P KeetonDivision of Child and Adolescent Psychiatry, The Johns Hopkins Hospital.
Cynthia M SuvegDepartment of Psychology, University of Georgia.
Sasha G AschenbrandDepartment of Child Psychiatry, Columbia University Medical Center.
Dara SakolskyWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center.
Satish IyengarWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center.
John T WalkupDivision of Child and Adolescent Psychiatry, Weill Cornell Medical College.
Anne Marie AlbanoDepartment of Child Psychiatry, Columbia University Medical Center.
University of Pittsburgh Medical Center · USColumbia University Irving Medical Center · USJohns Hopkins Hospital · USCornell University · USDuke Medical Center · USDuke University Hospital · USNational Institute of Mental Health · CZPhiladelphia College of Osteopathic Medicine · USTemple University · USUniversity of California, Los Angeles · USUniversity of Georgia · USUniversity of Michigan–Ann Arbor · US

Funding

THE REFINEMENT &APPLICATION OF MEDICAL DECISION MAKING IN PREVENTION SCIENCESP50DA010075 · NIDA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LI, RUNZE · 1996 to 2014
$24.5M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN · 2002 to 2007
$3.1M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2002 to 2007
$2.7M
Child/Adolescent Anxiety Multimodal Treatment Study (CAMS)U01MH064092 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ALBANO, ANNE MARIE · 2002 to 2007
$2.4M
Child and Adolescent Anxiety Multisite Study (CAMS)U01MH064107 · NIMH · DUKE UNIVERSITY · PI MARCH, JOHN S · 2002 to 2007
$2.4M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2002 to 2007
$2.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2002 to 2007
$2.1M
Statistics and Methodology in Clinical TrialsK23MH075843 · NIMH · DUKE UNIVERSITY · PI COMPTON, SCOTT N · 2007 to 2011
$819k
Integrating Biological Markers into Clinical ResearchK24MH096760 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GINSBURG, GOLDA SUSAN · 2013 to 2016
$653k
Discovering Tailoring Variables in Childhood Mental Health Treatment ResearchR03MH097954 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL · 2012 to 2013
$166k
NIDA NIH HHS P50 DA010075NIMH NIH HHS K23 MH075843NIMH NIH HHS K24 MH096760NIMH NIH HHS L40 MH072315NIMH NIH HHS R03 MH097954NIMH NIH HHS U01 MH063747NIMH NIH HHS U01 MH064003NIMH NIH HHS U01 MH064088NIMH NIH HHS U01 MH064089NIMH NIH HHS U01 MH064092NIMH NIH HHS U01 MH064107NIMH NIH HHS U01 MH63747NIMH NIH HHS U01 MH64003NIMH NIH HHS U01 MH64088NIMH NIH HHS U01 MH64092NIMH NIH HHS U01 MH64107
6 · The paper itself

Abstract

objectiveWe sought to examine predictors and moderators of treatment outcomes among 488 youths ages 7-17 years (50% female; 74% ≤ 12 years) meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; American Psychiatric Association, 2000) criteria for diagnoses of separation anxiety disorder, social phobia, or generalized anxiety disorder who were randomly assigned to receive either cognitive behavioral therapy (CBT), sertraline (SRT), their combination (COMB), or medication management with pill placebo (PBO) in the Child/Adolescent Anxiety Multimodal Study (CAMS).

methodSix classes of predictor and moderator variables (22 variables) were identified from the literature and examined using continuous (Pediatric Anxiety Ratings Scale; PARS) and categorical (Clinical Global Impression Scale-Improvement; CGI-I) outcome measures.

resultsThree baseline variables predicted better outcomes (independent of treatment condition) on the PARS, including low anxiety severity (as measured by parents and independent evaluators) and caregiver strain. No baseline variables were found to predict Week 12 responder status (CGI-I). Participants' principal diagnosis moderated treatment outcomes but only on the PARS. No baseline variables were found to moderate treatment outcomes on Week 12 responder status (CGI-I). DISCUSSION: Overall, anxious children responded favorably to CAMS treatments. However, having more severe and impairing anxiety, greater caregiver strain, and a principal diagnosis of social phobia were associated with less favorable outcomes. Clinical implications of these findings are discussed.

Indexed as

AdolescentAnxiety DisordersChildCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMaleSelective Serotonin Reuptake InhibitorsSertralineSocioeconomic FactorsTreatment OutcomeSelective Serotonin Reuptake InhibitorsSertraline

Identifiers

PMID24417601
PMCPMC4056442
OpenAlexW2046280100

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.