ArticleACS nano2014
Surface interactions with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportunities for safer design.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 248 citations in OpenAlex.
- Bridging Nano-Interface Interactions and Organ-Specific Toxicity: A Review of Machine Learning for Nanomaterials Risk Assessment.Molecules (Basel, Switzerland) · 2026Review
- Crystalline and Amorphous Cerium Phosphate Nanoparticles as Enzyme-Mimetic Nanomaterials for Regenerative Medicine.Nanomaterials (Basel, Switzerland) · 2026Article
- Advances in the Rational Design, Mechanisms, and Applications of Lanthanide Nanoparticles for the Regulation of Reactive Oxygen Species.International journal of nanomedicine · 2026Review
- Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes.Nature communications · 2025Article
- Multimodal feature fusion machine learning for predicting chronic injury induced by engineered nanomaterials.Nature communications · 2025Article
- Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis.Particle and fibre toxicology · 2025Article
- Impact of surface chemistry of upconversion nanoparticles on time-dependent cytotoxicity in non-cancerous epithelial cells.Scientific reports · 2024Article
- Oxide-Perovskites for Automotive Catalysts Biotransform and Induce Multicomponent Clearance and Hazard.ACS nano · 2024Article
- Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity.Journal of nanobiotechnology · 2024Article
- A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy.Chemical science · 2024Article
- Biocompatible Upconverting Nanoprobes for Dual-Modal Imaging and Temperature Sensing.ACS applied nano materials · 2024Article
- Design and Development of Gold/reduced Graphene Oxide Nanocomposite loaded with Cyclophosphamide: Potential Application in Treatment of Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Approaches to Nanoparticle Labeling: A Review of Fluorescent, Radiological, and Metallic Techniques.Environment & health (Washington, D.C.) · 2023Review
- Nanotechnology in Cancer Diagnosis and Treatment.Pharmaceutics · 2023Review
- The onset of rare earth metallosis begins with renal gadolinium-rich nanoparticles from magnetic resonance imaging contrast agent exposure.Scientific reports · 2023Article
- Dissolution Behaviour of Metal-Oxide Nanomaterials in Various Biological Media.Nanomaterials (Basel, Switzerland) · 2022Article
- Diverse Pathways of Engineered Nanoparticle-Induced NLRP3 Inflammasome Activation.Nanomaterials (Basel, Switzerland) · 2022Review
- Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages.Particle and fibre toxicology · 2021Article
- Biotransformation of rare earth oxide nanoparticles eliciting microbiota imbalance.Particle and fibre toxicology · 2021Article
- Nano-LaFrontiers in microbiology · 2021Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
Growing international exploitation of rare earth oxides (REOs) for commercial and biological use has increased the possibility of human exposure and adverse health effects. Occupational exposure to rare earth materials in miners and polishers leads to a severe form of pneumoconiosis, while gadolinium-containing MRI contrast agents cause nephrogenic systemic fibrosis in patients with renal impairment. The mechanisms for inducing these adverse pro-fibrogenic effects are of considerable importance for the safety assessment of REO particles as well as presenting opportunities for safer design. In this study, using a well-prepared REO library, we obtained a mechanistic understanding of how REOs induce cellular and pulmonary damage by a compartmentalized intracellular biotransformation process in lysosomes that results in pro-fibrogenic growth factor production and lung fibrosis. We demonstrate that rare earth oxide ion shedding in acidifying macrophage lysosomes leads to biotic phosphate complexation that results in organelle damage due to stripping of phosphates from the surrounding lipid bilayer. This results in nanoparticle biotransformation into urchin shaped structures and setting in motion a series of events that trigger NLRP3 inflammasome activation, IL-1β release, TGF-β1 and PDGF-AA production. However, pretreatment of REO nanoparticles with phosphate in a neutral pH environment prevents biological transformation and pro-fibrogenic effects. This can be used as a safer design principle for producing rare earth nanoparticles for biological use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.