Trial reportInternational journal of circumpolar health2013
Adherence and barriers to H. pylori treatment in Arctic Canada.
Trial report in International journal of circumpolar health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Feasibility, fidelity and initial effects of an app-based service for short-term antibiotic therapy: A pilot study in a primary care setting.Exploratory research in clinical and social pharmacy · 2026Article
- Adherence to Helicobacter pylori Management Consensus in Clinical Practice at Two Tertiary Hospitals: A Large Cohort Study.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Care-Seeking Action after Helicobacter pylori Testing among a High-Risk Indigenous Population: A Cross-Sectional Study Follow-up.The American journal of tropical medicine and hygiene · 2025Article
- Increasing our knowledge about the epidemiology ofInternational journal of circumpolar health · 2024Article
- Vonoprazan-amoxicillin dual regimen withWorld journal of gastroenterology · 2024Article
- Shifting paradigm from biomedical to decolonised methods in Inuit public health research in Canada: a scoping review.BMJ global health · 2022Article
- Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden ofGastro hep advances · 2022Article
- Socioeconomic and demographic factors associated with failure inGastroenterology and hepatology from bed to bench · 2021Article
- Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada.BMC public health · 2019Article
- Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities.BMC public health · 2019Article
- Disinfection and removal of human pathogenic bacteria in arctic waste stabilization ponds.Environmental science and pollution research international · 2018Article
- Outcomes of furazolidone- and amoxicillin-based quadruple therapy forWorld journal of gastroenterology · 2018Article
- First-line therapies forAnnals of gastroenterology · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHelicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for common stomach complaints, leading to frequent demand for treatment, which often fails. Moreover, public health authorities identified the need for information to develop locally appropriate H. pylori control strategies. We described adherence and identified barriers to completing treatment among H. pylori-positive participants in a community-based project inspired by local concerns about H. pylori infection risks.
methodsIn 2008, 110 H. pylori-positive participants (diagnosed by a breath test, histopathology and/or culture) of the Aklavik H. pylori project were randomised to standard-of-care or sequential treatment. We ascertained adherence by interviewing participants using a structured questionnaire. We estimated adherence frequencies as the proportion of participants who reported taking either 100% of doses (perfect adherence) or ≥80% of doses (good adherence). To compare the proportion with perfect or good adherence in subgroups, we report proportion differences and 95% confidence intervals (CI).
resultsOf 87 participants who were interviewed, 64% reported perfect adherence and 80% reported good adherence. We observed more frequent perfect adherence for: standard therapy (67%) versus sequential (62%); males (76%) versus females (52%); participants 40-77 years (79%) versus 17-39 (50%). Proportion differences were 5% (CI: -15, 25) for standard versus sequential therapy; 23% (CI: 4, 43) for male versus female; and 29% (CI: 10, 48) for 40-77 versus 15-39 years for perfect adherence. Of the 29 participants who reported poor adherence (<80% of doses taken), the following barriers to treatment were reported: changed mind about taking treatment (24%), consumption of alcoholic beverages (18%), nausea (18%), forgetfulness (12%), stomach pain (12%), difficulty in swallowing pills (6%), no reason (6%) or bad taste of the pills (6%).
conclusionThis analysis suggests that adherence to treatment for eliminating H. pyori infection may vary by regimen and may be influenced by socio-demographic factors. These findings add to the small body of evidence pertaining to adherence to H. pylori treatment in Arctic Aboriginal communities. On-going research in additional northern Canadian communities will accumulate data for developing recommendations to improve adherence for treatment to eliminate H. pylori infection.
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