ArticleJACC. Heart failure2013
Gene Expression Profiles of Peripheral Blood Mononuclear Cells Reveal Transcriptional Signatures as Novel Biomarkers for Cardiac Remodeling in Rats with Aldosteronism and Hypertensive Heart Disease.
Article in JACC. Heart failure, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 23 citations in OpenAlex.
- Association Between Inflammatory Markers and Myocardial Fibrosis.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Ribonucleic acid biomarkers for heart failure is there a correlation between heart and blood transcriptomics?JACC. Heart failure · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesIn searching for a noninvasive surrogate tissue having mimicry with the prooxidant/-proinflammatory hypertensive heart disease (HHD) phenotype, we turned to peripheral blood mononuclear cells (PBMC). We tested whether iterations in [Ca
backgroundInappropriate neurohormonal activation contributes to pathologic remodeling of myocardium in HHD associated with aldosteronism. In rats receiving chronic ALDOST, evidence of reparative fibrosis replacing necrotic cardiomyocytes and coronary vasculopathy appears at wk 4 associated with the induction of oxidative stress by mitochondria that overwhelms endogenous, largely Zn
methodsIn PBMC and cardiomyocytes, quantitation of cytoplasmic free Ca
resultsCompared to controls, at wk 1 and 4 ALDOST, we found comparable: increments in [Ca
conclusionsSignificant overlapping demonstrated in the molecular mimicry of PBMC and cardiomyocytes during preclinical and pathologic stages of ALDOST implicates that transcriptional signatures of PBMC may serve as early noninvasive and novel sentinels predictive of impending pathologic remodeling in HHD.
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