ArticleChemical science2014
Do Spin State and Spin Density Affect Hydrogen Atom Transfer Reactivity?
Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Multistate reactivity of weak-field clusters at ambient temperatures.Nature communications · 2026Review
- A 5,000-fold increase in the HAT reactivity of a nonheme FeProceedings of the National Academy of Sciences of the United States of America · 2025Article
- 10-Fold Increase in Hydrogen Atom Transfer Reactivity for a Series ofJournal of the American Chemical Society · 2025Article
- Photocatalytic systems: reactions, mechanism, and applications.RSC advances · 2024Review
- NMR and Mössbauer Studies Reveal a Temperature-Dependent Switch fromJournal of the American Chemical Society · 2024Article
- The role of basicity in selective C-H bond activation by transition metal-oxidos.Dalton transactions (Cambridge, England : 2003) · 2023Review
- Article
- Stabilization of a high-spin three-coordinate Fe(iii) imidyl complex by radical delocalization.Chemical science · 2022Article
- Determining the inherent selectivity for carbon radical hydroxylationRSC advances · 2022Article
- Enzyme-Like Hydroxylation of Aliphatic C-H Bonds From an Isolable Co-Oxo Complex.Journal of the American Chemical Society · 2021Article
- C-H Bond Cleavage by Bioinspired Nonheme Metal Complexes.Inorganic chemistry · 2021Review
- Semiempirical method for examining asynchronicity in metal-oxido-mediated C-H bond activation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Controlling Radical-Type Single-Electron Elementary Steps in Catalysis with Redox-Active Ligands and Substrates.JACS Au · 2021Review
- Local Electric Fields as a Natural Switch of Heme-Iron Protein Reactivity.ACS catalysis · 2021Article
- Tuning the H-Atom Transfer Reactivity of Iron(IV)-Oxo Complexes as Probed by Infrared Photodissociation Spectroscopy.Angewandte Chemie (International ed. in English) · 2021Article
- Statistical analysis of C-H activation by oxo complexes supports diverse thermodynamic control over reactivity.Chemical science · 2021Article
- Closed Shell Iron(IV) Oxo Complex with an Fe-O Triple Bond: Computational Design, Synthesis, and Reactivity.Angewandte Chemie (International ed. in English) · 2020Article
- A platinum(II) metallonitrene with a triplet ground state.Nature chemistry · 2020Article
- The oxidation of cyclo-olefin by the S = 2 ground-state complex [FeJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
- Chemoselectivity in the Oxidation of Cycloalkenes with a Non-Heme Iron(IV)-Oxo-Chloride Complex: Epoxidation vs. Hydroxylation Selectivity.Journal of the American Society for Mass Spectrometry · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The prevalence of hydrogen atom transfer (HAT) reactions in chemical and biological systems has prompted much interest in establishing and understanding the underlying factors that enable this reactivity. Arguments have been advanced that the electronic spin state of the abstractor and/or the spin-density at the abstracting atom are critical for HAT reactivity. This is consistent with the intuition derived from introductory organic chemistry courses. Herein we present an alternative view on the role of spin state and spin-density in HAT reactions. After a brief introduction, the second section introduces a new and simple fundamental kinetic analysis, which shows that unpaired spin cannot be the dominant effect. The third section examines published computational studies of HAT reactions, which indicates that the spin state affects these reactions indirectly, primarily via changes in driving force. The essay concludes with a broader view of HAT reactivity, including indirect effects of spin and other properties on reactivity. It is suggested that some of the controversy in this area may arise from the diversity of HAT reactions and their overlap with proton-coupled electron transfer (PCET) reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.