ArticlePloS one2014
Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review.Biochemia medica · 2016Pooled it
- Beyond Hemostasis: Platelets' Multifaceted Functions in Immune Responses.Life (Basel, Switzerland) · 2026Review
- Stability of immature platelets present in platelet units during hemoconcentration.Journal of thrombosis and thrombolysis · 2026Article
- Reticulated Platelets and an Optimal Model for Differentiating Thrombocytopenia Etiologies.EJHaem · 2026Article
- Applications of Extended Platelet Profiles in Clinical Practice.Diseases (Basel, Switzerland) · 2026Review
- Thrombocytopenia in Sepsis.Life (Basel, Switzerland) · 2025Review
- Novel Biomarkers for Diagnosis and Monitoring of Immune Thrombocytopenia.International journal of molecular sciences · 2023Review
- Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production.Clinical and experimental immunology · 2022Article
- Immature platelets in COVID-19 infection.British journal of haematology · 2021Article
- Immature platelet fraction: A useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery.Medicine · 2020Observational
- Immature Platelet Dynamics in Immune-Mediated Thrombocytopenic States.Frontiers in medicine · 2020Review
- Relationship between circulating microparticles and hypertension and other cardiac disease biomarkers in the elderly.BMC cardiovascular disorders · 2019Article
- Ultrastructural changes in peripheral blood leukocytes in α-synuclein knockout mice.Blood cells, molecules & diseases · 2018Article
- Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction.International journal of hematology · 2018Article
- Evaluation of the immature platelet fraction contribute to the differential diagnosis of hereditary, immune and other acquired thrombocytopenias.Scientific reports · 2017Article
- Platelet volume indices in patients with varicocele.Clinical and experimental reproductive medicine · 2014Article
- Transfusion efficacy of apheresis platelet concentrates irradiated at the day of transfusion is significantly superior compared to platelets irradiated in advance.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Article
- Sex-divided reference intervals for mean platelet volume, platelet large cell ratio and plateletcrit using the Sysmex XN-10 automated haematology analyzer in a UK population.Hematology, transfusion and cell therapyArticle
- A Nomogram for Predicting Infertility Risk in Patients With Varicocele Using Inflammatory Markers.American journal of men's healthArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating immature platelet fraction (IPF) reflects real-time thrombopoiesis and correlates with platelet recovery from thrombocytopenic presentations. To understand the dynamics of IPF in platelet transfusions, we quantified the %-IPF in single-donor platelet components (SDP) during prolonged storage. %-IPF significantly increased from baseline by day 5 post-donation. Absolute IPF counts (A-IPC) had similar significant increments. However, gamma-irradiation suppressed the increments of %-IPF and A-IPC by >50%. Ultrastructural analysis of SDP units at day 10 showed well preserved morphology of immature platelets. Our findings suggest that IPF might actively expand ex-vivo and may have a longer shelf life than their mature counterparts. Closer study of IPF may be of critical clinical importance for transfusion practices.
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