ArticlePloS one2014
Two-step source tracing strategy of Yersinia pestis and its historical epidemiology in a specific region.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Methods used in microbial forensics and epidemiological investigations for stronger health systems.Forensic sciences research · 2022Review
- Genetic source tracking of human plague cases in Inner Mongolia-Beijing, 2019.PLoS neglected tropical diseases · 2021Article
- Human plague associated with Tibetan sheep originates in marmots.PLoS neglected tropical diseases · 2018Article
- Epidemiological analysis of the Eyam plague outbreak of 1665-1666.Proceedings. Biological sciences · 2016Article
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17 authors.
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Abstract
Source tracing of pathogens is critical for the control and prevention of infectious diseases. Genome sequencing by high throughput technologies is currently feasible and popular, leading to the burst of deciphered bacterial genome sequences. Utilizing the flooding genomic data for source tracing of pathogens in outbreaks is promising, and challenging as well. Here, we employed Yersinia pestis genomes from a plague outbreak at Xinghai county of China in 2009 as an example, to develop a simple two-step strategy for rapid source tracing of the outbreak. The first step was to define the phylogenetic position of the outbreak strains in a whole species tree, and the next step was to provide a detailed relationship across the outbreak strains and their suspected relatives. Through this strategy, we observed that the Xinghai plague outbreak was caused by Y. pestis that circulated in the local plague focus, where the majority of historical plague epidemics in the Qinghai-Tibet Plateau may originate from. The analytical strategy developed here will be of great help in fighting against the outbreaks of emerging infectious diseases, by pinpointing the source of pathogens rapidly with genomic epidemiological data and microbial forensics information.
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