ArticlePloS one2014
Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans.Translational psychiatry · 2022Article
- Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- TBL1XR1 Ensures Balanced Neural Development Through NCOR Complex-Mediated Regulation of the MAPK Pathway.Frontiers in cell and developmental biology · 2021Article
- Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1β signaling.Scientific reports · 2020Article
- Fair-Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration.Molecular nutrition & food research · 2020Review
- Evaluation on monoamine neurotransmitters changes in depression rats given with sertraline, meloxicam or/and caffeic acid.Genes & diseases · 2019Article
- Social isolation improves the performance of rodents in a novel cognitive flexibility task.Frontiers in zoology · 2019Article
- Constructing an Inexpensive Elevated Plus Maze.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2018Article
- Visceral Inflammation and Immune Activation Stress the Brain.Frontiers in immunology · 2017Review
- Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice.Pharmacology, biochemistry, and behavior · 2015Article
- Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.Journal of Alzheimer's disease : JAD · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When 5-lipoxygenase (5-LO) is inhibited, roughly half of the CNS effect of the prototypic endocannabinoid anandamide (AEA) is lost. Therefore, we decided to investigate whether inhibiting this enzyme would influence physiological functions classically described as being under control of the endocannabinoid system. Although 5-LO inhibition by MK-886 reduced lipoxin A4 levels in the brain, no effect was found in the elevated plus maze (EPM), even at the highest possible doses, via i.p. (10 mg/kg,) or i.c.v. (500 pmol/2 µl) routes. Accordingly, no alterations in anxiety-like behavior in the EPM test were observed in 5-LO KO mice. Interestingly, aged mice, which show reduced circulating lipoxin A4 levels, were sensitive to MK-886, displaying an anxiogenic-like state in response to treatment. Moreover, exogenous lipoxin A4 induced an anxiolytic-like profile in the EPM test. Our findings are in line with other reports showing no difference between FLAP KO or 5-LO KO and their control strains in adult mice, but increased anxiety-like behavior in aged mice. We also show for the first time that lipoxin A4 affects mouse behavior. In conclusion, we propose an age-dependent relevancy of endogenous 5-LO derivatives in the modulation of anxiety-like behavior, in addition to a potential for exogenous lipoxin A4 in producing an anxiolytic-like state.
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