ArticlePloS one2014
Brain metabolism during hallucination-like auditory stimulation in schizophrenia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The efficacy and safety of continuous theta burst stimulation for auditory hallucinations: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2024Pooled it
- Brain glucose metabolism in schizophrenia: a systematic review and meta-analysis ofPsychological medicine · 2023Pooled it
- Neurovascular Uncoupling in Schizophrenia: A Bimodal Meta-Analysis of Brain Perfusion and Glucose Metabolism.Frontiers in psychiatry · 2020Pooled it
- Candidate Multimodal MRI Markers of Persistent Auditory Verbal Hallucinations: A Controlled Pilot Study.Tomography (Ann Arbor, Mich.) · 2026Observational
- Disrupted rest-task shift of multi-band electroencephalography complexity in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Distinct neural circuits processing pleasant and unpleasant sounds: an fMRI-based approach.BMC neuroscience · 2025Article
- Aberrant salience signaling in auditory processing in schizophrenia: Evidence for abnormalities in both sensory processing and emotional reactivity.Schizophrenia research · 2024Article
- On the 'Hallucinations' of Artificial Intelligence and the Hallucination Experience in Human.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2024Article
- A Characterization of the Effects of Minocycline Treatment During Adolescence on Structural, Metabolic, and Oxidative Stress Parameters in a Maternal Immune Stimulation Model of Neurodevelopmental Brain Disorders.The international journal of neuropsychopharmacology · 2021Article
- Local versus long-range connectivity patterns of auditory disturbance in schizophrenia.Schizophrenia research · 2021Article
- Differences in functional connectivity density among subtypes of schizophrenic auditory hallucination.Brain imaging and behavior · 2020Article
- Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes.Brain imaging and behavior · 2020Article
- Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia.Scientific reports · 2020Article
- Article
- Amygdalar Auditory Neurons Contribute to Self-Other Distinction during Ultrasonic Social Vocalization in Rats.Frontiers in neuroscience · 2016Article
- On the transmethylation hypothesis: stress, N,N-dimethyltryptamine, and positive symptoms of psychosis.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. These results suggest that abnormal modulation of the auditory cortex by limbic-thalamic structures might be involved in the pathophysiology of AVH and may potentially account for the emotional features that characterize hallucinatory percepts in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.