ArticlePloS one2014
Antiadhesive properties of Abelmoschus esculentus (Okra) immature fruit extract against Helicobacter pylori adhesion.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 83 citations in OpenAlex.
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- Understanding the traditional values and use of okra among pregnant women in western Ethiopia: a qualitative study.BMJ open · 2023Article
- Ellagitannins fromNutrients · 2023Article
- Accumulation and translocation of eight trace metals by the different tissues of Abelmoschus esculentus Moench. irrigated with untreated wastewater.Environmental science and pollution research international · 2022Article
- Okra (Plants (Basel, Switzerland) · 2021Review
- Anti-demodectic effects of okra eyelid patch inExperimental and therapeutic medicine · 2021Article
- Okra (Molecules (Basel, Switzerland) · 2021Review
- Adhesion ofFrontiers in molecular biosciences · 2021Review
- Abelmoschus esculentus (L.): Bioactive Components' Beneficial Properties-Focused on Antidiabetic Role-For Sustainable Health Applications.Molecules (Basel, Switzerland) · 2018Article
- Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy.Molecules (Basel, Switzerland) · 2018Article
- Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraditional Asian and African medicine use immature okra fruits (Abelmoschus esculentus) as mucilaginous food to combat gastritis. Its effectiveness is due to polysaccharides that inhibit the adhesion of Helicobacter pylori to stomach tissue. The present study investigates the antiadhesive effect in mechanistic detail. METHODOLOGY: A standardized aqueous fresh extract (Okra FE) from immature okra fruits was used for a quantitative in vitro adhesion assay with FITC-labled H. pylori J99, 2 clinical isolates, AGS cells, and fluorescence-activated cell sorting. Bacterial adhesins affected by FE were pinpointed using a dot-blot overlay assay with immobilized Lewis(b), sialyl-Lewis(a), H-1, laminin, and fibronectin. (125)I-radiolabeled Okra FE polymer served for binding studies to different H. pylori strains and interaction experiments with BabA and SabA. Iron nanoparticles with different coatings were used to investigate the influence of the charge-dependence of an interaction on the H. pylori surface. PRINCIPAL
findingsOkra FE dose-dependently (0.2 to 2 mg/mL) inhibited H. pylori binding to AGS cells. FE inhibited the adhesive binding of membrane proteins BabA, SabA, and HpA to its specific ligands. Radiolabeled compounds from FE bound non-specifically to different strains of H. pylori, as well as to BabA/SabA deficient mutants, indicating an interaction with a still-unknown membrane structure in the vicinity of the adhesins. The binding depended on the charge of the inhibitors. Okra FE did not lead to subsequent feedback regulation or increased expression of adhesins or virulence factors.
conclusionNon-specific interactions between high molecular compounds from okra fruits and the H. pylori surface lead to strong antiadhesive effects.
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