Evidence map›Paper›PMID 24416291›Full record

ArticlePloS one2014

Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.

Jochen Klenk, Kilian Rapp, Hanno Ulmer, Hans Concin, Gabriele Nagel

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  20. [Epidemiology of obesity in Austria].Wiener medizinische Wochenschrift (1946) · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jochen KlenkInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany ; Clinic for Geriatric Rehabilitation, Robert-Bosch Hospital, Stuttgart, Germany.
Kilian RappInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany ; Clinic for Geriatric Rehabilitation, Robert-Bosch Hospital, Stuttgart, Germany.
Hanno UlmerDepartment of Medical Statistics, Informatics and Health Economics, Medical University, Innsbruck, Austria.
Hans ConcinAgency for Preventive and Social Medicine, Bregenz, Austria.
Gabriele NagelInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany ; Agency for Preventive and Social Medicine, Bregenz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh Body-Mass-Index (BMI) is associated with increased all-cause mortality, but little is known about the effect of short- and long-term BMI change on mortality. The aim of the study was to determine how long-term weight change affects mortality. METHODS AND

findingsWithin a population-based prospective cohort of 42,099 Austrian men and women (mean age 43 years) with at least three BMI measurements we investigated the relationship of BMI at baseline and two subsequent BMI change intervals of five years each with all-cause mortality using Cox proportional Hazard models. During median follow-up of 12 years 4,119 deaths were identified. The lowest mortalities were found in persons with normal weight or overweight at baseline and stable BMI over 10 years. Weight gain (≥0.10 kg/m(2)/year) during the first five years was associated with increased mortality in overweight and obese people. For weight gain during both time intervals mortality risk remained significantly increased only in overweight (Hazard Ratio (HR): 1.39 (95% confidence interval: 1.01; 1.92)) and obese women (1.85 (95% confidence interval: 1.18; 2.89)). Weight loss (< -0.10 kg/m(2)/year) increased all-cause mortality in men and women consistently. BMI change over time assessed using accepted World Health Organisation BMI categories showed no increased mortality risk for people who remained in the normal or overweight category for all three measurements. In contrast, HRs for stable obese men and women were 1.57 (95% CI: 1.31; 1.87) and 1.46 (95% CI: 1.25; 1.71) respectively.

conclusionOur findings highlight the importance of weight stability and obesity avoidance in prevention strategy.

Indexed as

Body Mass IndexAdultCohort StudiesFemaleHumansMaleMortalityTime Factors

Identifiers

PMID24416291
PMCPMC3885599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.