Evidence map›Paper›PMID 24416245›Full record

ArticlePloS one2014

Regional neuroplastic brain changes in patients with chronic inflammatory and non-inflammatory visceral pain.

Jui-Yang Hong, Jennifer S Labus, Zhiguo Jiang, Cody Ashe-Mcnalley, Ivo Dinov, Arpana Gupta, Yonggang Shi, Jean Stains, Nuwanthi Heendeniya, Suzanne R Smith and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Immunoception: the insular cortex perspective.Cellular & molecular immunology · 2023
    Review
  10. Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023
    Article
  11. Article
  12. Impact of the COVID-19 pandemic on inflammatory bowel disease: The role of emotional stress and social isolation.Stress and health : journal of the International Society for the Investigation of Stress · 2022
    Article
  13. Article
  14. Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022
    Review
  15. Extending the Common Sense Model to Explore the Impact of Visceral Sensitivity on Quality of Life in Inflammatory Bowel Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jui-Yang HongGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America.
Jennifer S LabusGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Zhiguo JiangDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, United States of America ; Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America.
Cody Ashe-McnalleyGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Ivo DinovUniversity of Michigan School of Nursing, Ann Arbor, Michigan, United States of America.
Arpana GuptaGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Yonggang ShiLaboratory of Neuro-Imaging, University of Southern California, Los Angeles, California United States of America.
Jean StainsGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Nuwanthi HeendeniyaGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Suzanne R SmithGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Kirsten TillischGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
Emeran A MayerGail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Psychiatry, University of California Los Angeles, Los Angeles, California, United States of America ; Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America ; Ahmanson Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, Los Angeles, California.
University of California, Los Angeles · USPancreatic Cancer Action Network · USKessler Foundation · USMichigan United · USUniversity of Southern California · US

Funding

Center for Computational Biology (RMI)U54RR021813 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2004 to 2010
$25.3M
FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 1998 to 2011
$21.9M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
Neuroimaging biomarkers of Mind-Body treatment response in chronic visceral painR01AT007137 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NALIBOFF, BRUCE D, TILLISCH, KIRSTEN · 2011 to 2015
$2.7M
Central and Peripheral Autonomic Responses in Irritable Bowel SyndromeK23DK073451 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TILLISCH, KIRSTEN · 2006 to 2010
$625k
Effective connectivity of central response to Irritable Bowel Syndrome (IBS)K08DK071626 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LABUS, JENNIFER S · 2006 to 2010
$607k
NCCIH NIH HHS R01 AT007137NCRR NIH HHS 2-P41-RR-013642-15NCRR NIH HHS P41 RR013642NCRR NIH HHS U24 RR021992NCRR NIH HHS U24-RR021992NCRR NIH HHS U24 RR025736NCRR NIH HHS U24-RR025736NCRR NIH HHS U54 RR021813NIBIB NIH HHS 9P41EB015922-15NIBIB NIH HHS P41 EB015922NIDDK NIH HHS K08 DK071626NIDDK NIH HHS K23 DK073451NIDDK NIH HHS K23DK073451NIDDK NIH HHS P30 DK041301NIDDK NIH HHS P50 DK064539NIDDK NIH HHS R01 DK048351NIDDK NIH HHS R03 DK084169NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

Regional cortical thickness alterations have been reported in many chronic inflammatory and painful conditions, including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS), even though the mechanisms underlying such neuroplastic changes remain poorly understood. In order to better understand the mechanisms contributing to grey matter changes, the current study sought to identify the differences in regional alterations in cortical thickness between healthy controls and two chronic visceral pain syndromes, with and without chronic gut inflammation. 41 healthy controls, 11 IBS subjects with diarrhea, and 16 subjects with ulcerative colitis (UC) underwent high-resolution T1-weighted magnetization-prepared rapid acquisition gradient echo scans. Structural image preprocessing and cortical thickness analysis within the region of interests were performed by using the Laboratory of Neuroimaging Pipeline. Group differences were determined using the general linear model and linear contrast analysis. The two disease groups differed significantly in several cortical regions. UC subjects showed greater cortical thickness in anterior cingulate cortical subregions, and in primary somatosensory cortex compared with both IBS and healthy subjects. Compared with healthy subjects, UC subjects showed lower cortical thickness in orbitofrontal cortex and in mid and posterior insula, while IBS subjects showed lower cortical thickness in the anterior insula. Large effects of correlations between symptom duration and thickness in the orbitofrontal cortex and postcentral gyrus were only observed in UC subjects. The findings suggest that the mechanisms underlying the observed gray matter changes in UC subjects represent a consequence of peripheral inflammation, while in IBS subjects central mechanisms may play a primary role.

Indexed as

Neuronal PlasticityAdultBehaviorBrainCase-Control StudiesCognitionColitis, UlcerativeFemaleHumansInflammatory Bowel DiseasesMaleMiddle AgedNeuroimagingOrgan SizeSomatosensory CortexTomography, X-Ray Computed

Identifiers

PMID24416245
PMCPMC3885578
OpenAlexW2037162646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.