ArticlePloS one2014
Immune mediated shaping of microflora community composition depends on barrier site.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Langerhans cells: Central players in the pathophysiology of atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- B cell senescence promotes age-related changes in oral microbiota.Aging cell · 2024Article
- Unlocking Modifiable Risk Factors for Alzheimer's Disease: Does the Oral Microbiome Hold Some of the Keys?Journal of Alzheimer's disease : JAD · 2023Review
- Ecological Processes and Human Behavior Provide a Framework for Studying the Skin Microbial Metacommunity.Microbial ecology · 2022Review
- A Pilot Study: Favorable Effects ofCancers · 2022Article
- Early life host-microbe interactions in skin.Cell host & microbe · 2022Review
- IL-17 and IL-22 are pivotal cytokines to delay wound healing ofFrontiers in immunology · 2022Article
- A Pilot Study: Changes of Intestinal Microbiota of Patients With Non-small Cell Lung Cancer in Response to Osimertinib Therapy.Frontiers in microbiology · 2020Article
- The influence of the microbiome on respiratory health.Nature immunology · 2019Review
- Skin-Associated B Cells in Health and Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Article
- The influence of skin microorganisms on cutaneous immunity.Nature reviews. Immunology · 2016Review
- Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria.Nature communications · 2015Article
- Altered Gut Microbiota Composition in Rag1-deficient Mice Contributes to Modulating Homeostasis of Hematopoietic Stem and Progenitor Cells.Immune network · 2015Article
- Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Interactions between host factors and the skin microbiome.Cellular and molecular life sciences : CMLS · 2015Review
- Diet dominates host genotype in shaping the murine gut microbiota.Cell host & microbe · 2015Article
- Modulation of host responses by oral commensal bacteria.Journal of oral microbiology · 2015Article
- Regulation of the gut microbiota by the mucosal immune system in mice.International immunology · 2014Review
- Mechanisms regulating skin immunity and inflammation.Nature reviews. Immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Barrier surfaces, such as the intestinal lining and the skin, are colonized by a diverse community of commensal microorganisms. Although commensal microorganisms clearly impact the host immune system, whether the immune system also shapes the commensal community is poorly understood. We used 16S rDNA deep sequencing to test whether mice with specific immune defects have an altered commensal microflora. Initially, skin swabs were obtained from wild-type and Langerhans Cell (LC) deficient mice. Despite the intimate contacts that LC make with the upper epidermis, no significant differences were observed in microbial community composition. Similarly, the skin of MyD88/TRIF(-/-), Rag1(-/-) and heterozygous littermate controls showed no alteration in their commensal communities. Next we examined mouth swabs and feces. We did not find a difference in the MyD88/TRIF(-/-) mice. However, we did observe a significant shift in the microbial composition in the feces and mouths of Rag1(-/-) mice. Thus, we conclude that the adaptive immune system modulates the microbial composition at mucosal surfaces in the steady-state but LC, adaptive immunity, and MyD88-dependent innate responses do not affect the skin microbiome revealing a major distinction between barrier sites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.