Evidence map›Paper›PMID 24416185›Full record

ArticlePloS one2014

Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the Hunter Community Study.

Khanrin P Vashum, Mark McEvoy, Abul Hasnat Milton, Md Rafiqul Islam, Stephen Hancock, John Attia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

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  17. Antioxidant role of zinc in diabetes mellitus.World journal of diabetes · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Khanrin P VashumCentre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Abul Hasnat MiltonCentre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Md Rafiqul IslamCentre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia ; Ministry of Health and Family Welfare, Government of Bangladesh, Dhaka, Bangladesh.
Stephen HancockCentre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
John AttiaCentre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle, and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Hunter Medical Research Institute · AUMinistry of Health and Family Welfare · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups and if this is associated with pancreatic beta cell function and insulin sensitivity in the former 2 groups.

methodCross sectional study of a random sample of older community-dwelling men and women in Newcastle, New South Wales, Australia. Beta cell function, insulin sensitivity and insulin resistance were calculated for normoglycaemic and prediabetes participants using the Homeostasis Model Assessment (HOMA-2) calculator.

resultA total of 452 participants were recruited for this study. Approximately 33% (N = 149) had diabetes, 33% (N = 151) had prediabetes and 34% (N = 152) were normoglycaemic. Homeostasis Model Assessment (HOMA) parameters were found to be significantly different between normoglycaemic and prediabetes groups (p<0.001). In adjusted linear regression, higher serum zinc concentration was associated with increased insulin sensitivity (p = 0.01) in the prediabetic group. There was also a significant association between smoking and worse insulin sensitivity.

conclusionHigher serum zinc concentration is associated with increased insulin sensitivity. Longitudinal studies are required to determine if low serum zinc concentration plays a role in progression from pre-diabetes to diabetes.

Indexed as

Insulin ResistanceResidence CharacteristicsAgedAged, 80 and overBlood GlucoseFastingFemaleHomeostasisHumansInsulin-Secreting CellsLinear ModelsMaleMiddle AgedPrediabetic StateZincBlood GlucoseZinc

Identifiers

PMID24416185
PMCPMC3885544
OpenAlexW1976457425

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.