ArticlePloS one2014
Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Transcriptomic changes associated with maternal care in the brain of mouthbrooding cichlid Astatotilapia burtoni reflect adaptation to self-induced metabolic stress.The Journal of experimental biology · 2023Article
- Gene expression in the amygdala and hippocampus of cyclic and acyclic gilts.Journal of animal science · 2022Article
- Neurotranscriptomic changes associated with chick-directed parental care in adult non-reproductive Japanese quail.Scientific reports · 2021Article
- Review
- Neurotensin: A novel mediator of ovulation?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Neurotensin in reward processes.Neuropharmacology · 2020Review
- Article
- Down-regulation of fatty acid binding protein 7 (Fabp7) is a hallmark of the postpartum brain.Journal of chemical neuroanatomy · 2018Article
- Genetic and neuroendocrine regulation of the postpartum brain.Frontiers in neuroendocrinology · 2016Review
- MicroRNA expression is altered in lateral septum across reproductive stages.Neuroscience · 2016Article
- Song in an Affiliative Context Relates to the Neural Expression of Dopamine- and Neurotensin-Related Genes in Male European Starlings.Brain, behavior and evolution · 2016Article
- Neurotensin neural mRNA expression correlates with vocal communication and other highly-motivated social behaviors in male European starlings.Physiology & behavior · 2015Article
- Maternally responsive neurons in the bed nucleus of the stria terminalis and medial preoptic area: Putative circuits for regulating anxiety and reward.Frontiers in neuroendocrinology · 2015Review
- Kinetics of the early events of GPCR signalling.FEBS letters · 2014Article
- Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens.Frontiers in behavioral neuroscience · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotensin (NT) is a neuropeptide identical in mice and humans that is produced and released in many CNS regions associated with maternal behavior. NT has been linked to aspects of maternal care and previous studies have indirectly suggested that endogenous NT signaling is altered in the postpartum period. In the present study, we directly examine whether NT and its receptors exhibit altered gene expression in maternal relative to virgin outbred mice using real time quantitative PCR (qPCR) across multiple brain regions. We also examine NT protein levels using anti-NT antibodies and immunohistochemistry in specific brain regions. In the medial preoptic area (MPOA), which is critical for maternal behaviors, mRNA of NT and NT receptor 3 (Sort1) were significantly up-regulated in postpartum mice compared to virgins. NT mRNA was also elevated in postpartum females in the bed nucleus of the stria terminalis dorsal. However, in the lateral septum, NT mRNA was down-regulated in postpartum females. In the paraventricular nucleus of the hypothalamus (PVN), Ntsr1 expression was down-regulated in postpartum females. Neurotensin receptor 2 (Ntsr2) expression was not altered in any brain region tested. In terms of protein expression, NT immunohistochemistry results indicated that NT labeling was elevated in the postpartum brain in the MPOA, lateral hypothalamus, and two subregions of PVN. Together, these findings indicate that endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors.
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