Evidence map›Paper›PMID 24416139›Full record

SynthesisPloS one2014

Association between HIV/AIDS and multi-drug resistance tuberculosis: a systematic review and meta-analysis.

Yonatan Moges Mesfin, Damen Hailemariam, Sibhatu Biadgilign, Sibhatu Biadglign, Kelemu Tilahun Kibret

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 80 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  14. Article
  15. Drug resistance pulmonary tuberculosis among prisoners in Ethiopia: A systematic review andJournal of clinical tuberculosis and other mycobacterial diseases · 2026
    Review
  16. Article
  17. Patient-centred interventions for drug-resistant tuberculosis: A scoping review.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
    Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
    Biadglign, Sibhatu [corrected to Biadgilign, Sibhatu]
5 · Who and what money

Authors and funding

5 authors.

Yonatan Moges MesfinDepartment of Public Health, College of Medical and Health Science, Haramaya University, Harar, Ethiopia.
Damen HailemariamSchool of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.
Sibhatu Biadgilign
Sibhatu BiadglignFreelance Public Health Research Consultant, Addis Ababa, Ethiopia.
Kelemu Tilahun KibretDepartment of Public Health, College of Medical and Health Science, Wollega University, Nekemte, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV), multi-drug resistant tuberculosis (MDR) is emerging as major challenge facing tuberculosis control programs worldwide particularly in Asia and Africa. Findings from different studies on associations of HIV co-infection and drug resistance among patients with TB have been contradictory (discordant). Some institution based studies found strongly increased risks for multi-drug resistant TB (MDR TB) among patients co-infected with TB and HIV, whereas other studies found no increased risk (it remains less clear in community based studies. The aim was to conduct a systematic review and meta-analysis of the association between multi-drug resistant tuberculosis and HIV infection. METHODS AND

findingsSystematic review of the published literature of observational studies was conducted. Original studies were identified using databases of Medline/Pubmed, Google Scholar and HINARI. The descriptions of original studies were made using frequency and forest plot. Publication bias was assessed using Funnel plot graphically and Egger weighted and Begg rank regression tests statistically. Heterogeneity across studies was checked using Cochrane Q test statistic and I(2). Pool risk estimates of MDR-TB and sub-grouping analysis were computed to analyze associations with HIV. Random effects of the meta-analysis of all 24 observational studies showed that HIV is associated with a marginal increased risk of multi-drug resistant tuberculosis (estimated Pooled OR 1.24; 95%, 1.04-1.43). Subgroup analyses showed that effect estimates were higher (Pooled OR 2.28; 95%, 1.52-3.04) for primary multi-drug resistance tuberculosis and moderate association between HIV/AIDS and MDR-TB among population based studies and no significant association in institution settings.

conclusionsThis study demonstrated that there is association between MDR-TB and HIV. Capacity for diagnosis of MDR-TB and initiating and scale up of antiretroviral treatment, and collaborations between HIV and TB control programs need to be considered and strengthened.

Indexed as

Acquired Immunodeficiency SyndromeConfidence IntervalsGenetic HeterogeneityHumansObservational Studies as TopicPublication BiasTuberculosis, Multidrug-Resistant

Identifiers

PMID24416139
PMCPMC3885391

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.