ReviewKorean journal of pediatrics2013
Inflammation and hyponatremia: an underrecognized condition?
Review in Korean journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Association of hyponatremia and risk of in-hospital mortality in patients with acute stroke: a systematic review and meta-analysis.Frontiers in stroke · 2026Pooled it
- Influencing factors for surgical treatment in neonatal necrotizing enterocolitis: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Postoperative Hyponatremia After Pleural Symphysis.Annals of thoracic surgery short reports · 2026Article
- Synergistic Effects of Normal-Range Serum Sodium and Potassium on Mortality: The Modifying Role of Inflammation From a NHANES Cohort Analysis.Chronic diseases and translational medicine · 2026Article
- Urine protein electrophoresis analysis in dogs with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2026Article
- Hyponatremia upon PICU admission: a 10-year retrospective analysis of outcomes and independent prognostic value.BMC pediatrics · 2026Observational
- Clinical characteristics and emergency department-based warning indicators of fulminant myocarditis in children.PloS one · 2026Article
- Development and validation of a nomogram based on C-reactive protein, neutrophil count, and respiratory rate for predicting complicated appendicitis in children.Pediatric surgery international · 2025Article
- ROHHAD NET in Retrospect: Key Lessons Learned from Five Cases.Indian journal of pediatrics · 2025Article
- Unclear prognostic significance of mild hyponatremia in children referred to the emergency department.BMC pediatrics · 2025Article
- Dysfunction of Microcirculation in Atherosclerosis: Implications of Nitric Oxide, Oxidative Stress, and Inflammation.International journal of molecular sciences · 2025Review
- Disproportionality analysis of adverse events associated with ipilimumab and nivolumab combination therapy based on FAERS database.Scientific reports · 2025Article
- Article
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients.Clinical, cosmetic and investigational dermatology · 2025Article
- Serum sodium within the normal range and its U-shaped relationship with biological aging in U.S. adults.Frontiers in nutrition · 2025Article
- Association between hyponatremia and disease severity in pediatric urinary tract infections.BMC pediatrics · 2024Article
- Impact of Hyponatremia and ADH Secretion in MIS-C and COVID-19: An Integrative Approach of Prognostic and Diagnostic Markers.Current issues in molecular biology · 2024Article
- A Study of Hydroelectrolytic and Acid-Base Disturbances in MIS-C Patients: A Perspective on Antidiuretic Hormone Secretion.Current issues in molecular biology · 2024Article
- Rhinovirus infection presenting with symptomatic hyponatremia-Atypical presentation of a common infection.Clinical case reports · 2024Article
- Successful Treatment of SIADH after Removal of Ruptured Breast Implants.Plastic and reconstructive surgery. Global open · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Timely diagnosis of hyponatremia is important for preventing potential morbidity and mortality as it is often an indicator of underlying disease. The most common cause of eurvolemic hyponatremia is the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Recent studies have demonstrated that proinflammatory cytokines such as interleukin (IL) 1β and IL-6 are involved in the development of hyponatremia, a condition that is associated with severe inflammation and is related to antidiuretic hormone (ADH) secretion. Serum sodium levels in hyponatremia are inversely correlated with the percentage of neutrophils, C-reactive protein, and N-terminal-pro brain type natriuretic peptide. Additionally, elevated levels of serum IL-6 and IL-1β are found in inflammatory diseases, and their levels are higher in patients with hyponatremia. Because it is significantly correlated with the degree of inflammation in children, hyponatremia could be used as a diagnostic marker of pediatric inflammatory diseases. Based on available evidence, we hypothesize that hyponatremia may be associated with inflammatory diseases in general. Understanding the mechanisms responsible for augmented ADH secretion during inflammation, monitoring patient sodium levels, and selecting the appropriate intravenous fluid treatment are important components that may lower the morbidity and mortality of patients in a critical condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.