Evidence map›Paper›PMID 24415997›Full record

ReviewFrontiers in molecular neuroscience2013

Long non-coding RNAs in neurodevelopmental disorders.

Ilse I G M van de Vondervoort, Peter M Gordebeke, Nima Khoshab, Paul H E Tiesinga, Jan K Buitelaar, Tamas Kozicz, Armaz Aschrafi, Jeffrey C Glennon

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
  6. Article
  7. Review
  8. Focus on your locus with a massively parallel reporter assay.Journal of neurodevelopmental disorders · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Genomic data mining for functional annotation of human long noncoding RNAs.Journal of Zhejiang University. Science. B · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ilse I G M van de VondervoortDepartment of Cognitive Neuroscience, RadboudUMC Nijmegen, Netherlands ; Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior Nijmegen, Netherlands.
Peter M GordebekeCentre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior Nijmegen, Netherlands ; Department of Neuroinformatics, Radboud University Nijmegen, Netherlands.
Nima KhoshabDepartment of Neuroinformatics, Radboud University Nijmegen, Netherlands.
Paul H E TiesingaCentre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior Nijmegen, Netherlands ; Department of Neuroinformatics, Radboud University Nijmegen, Netherlands.
Jan K BuitelaarDepartment of Cognitive Neuroscience, RadboudUMC Nijmegen, Netherlands.
Tamas KoziczCentre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior Nijmegen, Netherlands ; Department of Anatomy, Radboud University Nijmegen, Netherlands.
Armaz AschrafiCentre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior Nijmegen, Netherlands ; Department of Neuroinformatics, Radboud University Nijmegen, Netherlands.
Jeffrey C GlennonDepartment of Cognitive Neuroscience, RadboudUMC Nijmegen, Netherlands ; Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior Nijmegen, Netherlands.
Netherlands Institute for Neuroscience · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive. Improved understanding of these mechanisms is critical, because the majority of the mammalian genome is transcribed, in most cases resulting in non-coding RNA products. Recent studies have suggested the involvement of lncRNA in neurobehavioral and neurodevelopmental disorders, highlighting the functional importance of this subclass of brain-enriched RNAs. Impaired expression of lnRNAs has been implicated in several forms of intellectual disability disorders. However, the role of this family of RNAs in cognitive function is largely unknown. Here we provide an overview of recently identified mechanisms of neuronal development involving lncRNAs, and the consequences of lncRNA deregulation for neurodevelopmental disorders.

Indexed as

autism spectrum disordersfragile X syndromegenomic imprintingintellectual disabilitylong non-coding RNAnervous system developmentschizophrenia

Identifiers

PMID24415997
PMCPMC3874560
OpenAlexW2143980011

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.