Evidence map›Paper›PMID 24415875›Full record

ArticleWorld journal of gastroenterology2014

Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions.

Patricia Sarlos, Dalma Varszegi, Veronika Csongei, Lili Magyari, Luca Jaromi, Lajos Nagy, Bela Melegh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn's disease and ulcerative colitis: evidence from 41 studies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Pooled it
  2. Pooled it
  3. Article
  4. World journal of gastroenterology · 2017
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Patricia SarlosPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
Dalma VarszegiPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
Veronika CsongeiPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
Lili MagyariPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
Luca JaromiPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
Lajos NagyPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
Bela MeleghPatricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the inflammatory bowel disease-5 locus (IBD5) and interleukin-23 receptor (IL23R) gene variants in UC patients and test for gene-gene interaction.

methodsThe study population (n = 625) was comprised of 320 unrelated ulcerative colitis (UC) patients with Caucasian origin and 316 age- and gender-matched, healthy controls. Five variants in the IBD5 locus (IGR2198a_1 rs11739135, IGR2096a_1 rs12521868, IGR2230a_1 rs17622208, SLC22A4 rs1050152 and SLC22A5 rs2631367) and two of the IL23R gene (rs1004819, rs2201841) were analysed. PCR and restriction fragment length polymorphism methods were used for genotyping, the SLC22A4 rs1050152 genotypes were determined by direct sequencing. Interactions and specific genotype combinations of the seven variants were tested by binary logistic regression analysis. The IL23R genotypes were stratified by IBD5 genotypes for further interaction analyses.

resultsFor the IL23R rs1004819 A allele we found significantly higher allele frequency (P = 0.032) in UC patients compared to control subjects. The SNP rs1004819 showed significant association with UC risk for carriers (P = 0.004, OR = 1.606; 95%CI: 1.160-2.223) and the SNP rs2201841 for homozygotes (P = 0.030, OR = 1.983; 95%CI: 1.069-3.678). Individually none of the IBD5 markers conferred risk to UC development. There was no evidence for statistical interaction either between IBD5 loci and IL23R genes using logistic regression analysis. After genotype stratification, we could detect a positive association on the background of rs1004819 A allele for SLC22A4 T, SLC22A5 C, IGR2198a_1 C or IGR2096a_1 T allele, the highest OR was calculated in the presence of SLC22A4 T allele (P = 0.005, OR = 2.015; 95%CI: 1.230-3.300). There was no association with UC for any combinations of rs1004819 and IGR2230a_1. The IL23R rs2201841 homozygous genotype and IBD5 carrier status together did not confer susceptibility for UC.

conclusionThe present study has shown that UC susceptibility genes are likely to act in a complex interactive manner similar to CD.

Indexed as

Epistasis, GeneticGenetic LociAdultCase-Control StudiesChi-Square DistributionColitis, UlcerativeFemaleGene FrequencyGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansHungaryInflammatory Bowel DiseasesLogistic ModelsMaleIL23R protein, humanOrganic Cation Transport ProteinsReceptors, InterleukinSLC22A4 protein, humanSymportersGene-gene interactionInflammatory bowel diseaseInflammatory bowel disease-5 locusInterleukin-23 receptor geneUlcerative colitis

Identifiers

PMID24415875
PMCPMC3886011
OpenAlexW2019125095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.