ArticleJournal of bacteriology2014
Bacterial flagellin-specific chaperone FliS interacts with anti-sigma factor FlgM.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Flagellin FLiS improves the resistance of cotton to Verticillium wilt through the signaling pathways of salicylic acid and jasmonic acid.Frontiers in plant science · 2025Article
- Structure, Assembly, and Function of Flagella Responsible for Bacterial Locomotion.EcoSal Plus · 2023Review
- Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure.International journal of molecular sciences · 2021Review
- Review
- Multiple Roles of Flagellar Export Chaperones for Efficient and Robust Flagellar Filament Formation inFrontiers in microbiology · 2021Article
- Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.Journal of bacteriology · 2020Article
- Inefficient Secretion of Anti-sigma Factor FlgM Inhibits Bacterial Motility at High Temperature.iScience · 2019Article
- Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein.Microbial cell factories · 2019Article
- Essential Role of σ Factor RpoF in Flagellar Biosynthesis and Flagella-Mediated Motility ofFrontiers in microbiology · 2019Article
- Piperine, an alkaloid inhibiting the super-relaxed state of myosin, binds to the myosin regulatory light chain.Archives of biochemistry and biophysics · 2018Article
- Fungal networks shape dynamics of bacterial dispersal and community assembly in cheese rind microbiomes.Nature communications · 2018Article
- Dynamics and Control of Flagella Assembly inFrontiers in cellular and infection microbiology · 2018Article
- Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C.Scientific reports · 2017Article
- Importance ofFrontiers in microbiology · 2017Article
- Comparative genomic analysis of the flagellin glycosylation island of the Gram-positive thermophile Geobacillus.BMC genomics · 2016Article
- Mathematical model of flagella gene expression dynamics in Salmonella enterica serovar typhimurium.Systems and synthetic biology · 2015Article
- Functional role of bdm during flagella biogenesis in Escherichia coli.Current microbiology · 2015Article
- Article
- Analysis of factors that affect FlgM-dependent type III secretion for protein purification with Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Flagella are extracellular organelles that propel bacteria. Each flagellum consists of a basal body, a hook, and a filament. The major protein of the filament is flagellin. Induction of flagellin gene expression coincides with secretion of FlgM. The role of FlgM is to inhibit FliA (σ(28)), a flagellum-specific RNA polymerase responsible for flagellin transcription. To prevent premature polymerization of newly synthesized flagellin molecules, FliS, the flagellin-specific chaperone, binds flagellin and facilitates its export. In this study, the interaction between FlgM and FliS from Salmonella enterica serovar Typhimurium was characterized using gel shift, intrinsic tryptophan fluorescence, circular dichroism, limited proteolysis, and cross-linking. We have demonstrated that (i) FliS and FlgM interact specifically, forming a 1:1 complex, (ii) the FliS binding site on FlgM is proximal to or even overlaps the binding site for FliA, and (iii) FliA competes with FliS for FlgM binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.