ArticleObesity (Silver Spring, Md.)2014
Alloisoleucine differentiates the branched-chain aminoacidemia of Zucker and dietary obese rats.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review.Journal of diabetes research · 2016Pooled it
- Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy.Cardiovascular diabetology · 2025Article
- Synergistic Combinations of Gut- and Pancreas-Hormone-Based Therapies: Advancements in Treatments for Metabolic Diseases.Endocrinology · 2023Review
- Unlocking the Potential: Amino Acids' Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus.Metabolites · 2023Review
- Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement.Nature aging · 2023Article
- CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.The Journal of biological chemistry · 2023Article
- Metabolic modelling of the human gut microbiome in type 2 diabetes patients in response to metformin treatment.NPJ systems biology and applications · 2023Article
- Predictive Gestational Diabetes Biomarkers With Sustained Alterations Throughout Pregnancy.Journal of the Endocrine Society · 2022Review
- Metabolic signatures of insulin resistance in non-diabetic individuals.BMC endocrine disorders · 2022Article
- Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes.Nutrition & diabetes · 2022Review
- Association of circulating branched-chain amino acids with risk of moyamoya disease.Frontiers in nutrition · 2022Article
- Effects ofAnnals of medicine · 2021Article
- Cardiac Energy Metabolism in Heart Failure.Circulation research · 2021Review
- Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice.Frontiers in pharmacology · 2021Article
- Metabolomics and Proteomics in Type 2 Diabetes.Circulation research · 2020Review
- The effect of eight-week walking program on plasma levels of amino acids in early/mid pubertal obese girls.Medical journal of the Islamic Republic of Iran · 2019Article
- Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span.APL bioengineering · 2018Article
- A Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk.Journal of the National Cancer Institute · 2018Article
- Serum metabolomic profile of incident diabetes.Diabetologia · 2018Article
- The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance.Experimental & molecular medicine · 2016Review
Corrections and comments
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Authors and funding
5 authors.
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Abstract
objectiveCirculating branched-chain amino acids (BCAAs) are elevated in obesity and this has been linked to obesity comorbidities. However it is unclear how obesity affects alloisoleucine, a BCAA and pathognomonic marker of branched-chain keto acid dehydrogenase complex (BCKDC) disorders. It has been previously established that obese Zucker rats exhibit BCKDC impairments in fat and other tissues, whereas BCKDC impairments in adipose tissue of DIO rats are compensated by increased hepatic BCKDC activity. Therefore, alloisoleucine was investigated in these two obesity models.
methodsAmino acids were extracted from plasma and measured using ultra performance liquid chromatography mass spectrometry.
resultsPlasma alloisoleucine was 238% higher in obese compared to lean Zucker rats. This elevation was greater than that of other BCAAs (107-124%). DIO rats had no significant change in alloisoleucine, despite elevations in other BCAAs (15-66%).
conclusionsAlloisoleucine was elevated in obese Zucker but not DIO rats consistent with known global impairments of BCKDC in Zucker but not DIO rats. Cytotoxic branched-chain ketoacids (BCKAs) accumulate in genetic disorders affecting BCKDC. BCKAs increase reactive oxygen species, stress kinase activation, and mitochondrial dysfunction. Inasmuch as these factors underlie obesity comorbidities, it may important to identify obese individuals with elevated alloisoleucine.
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