Evidence map›Paper›PMID 24415610›Full record

SynthesisInternational journal of epidemiology2013

Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis.

David G Dillon, Deepti Gurdasani, Johanna Riha, Kenneth Ekoru, Gershim Asiki, Billy N Mayanja, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina Njelekela and 41 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03106480 (Diabetes and Associated Complications in HIV Patients), which is not on this map. Cited by 133 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 13 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03106480 unknown statusnot on this mapstarted 2016, after this paper: background citation

Diabetes and Associated Complications in HIV Patients

TypeobservationalSponsorNational Institute for Medical Research, TanzaniaRan2016 to 2022Enrolled1,947ConditionsDiabetes Mellitus, HIV/AIDS
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 13 syntheses or guidelines pooled it, 199 citations in OpenAlex.

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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

51 authors at 5 institutions in 3 countries.

David G DillonDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK, Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda, Division of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Chronic Diseases Initiative in Africa, Department of Chemical Pathology, National Health Laboratory Service, University of the Witwatersrand Medical School, Johannesburg, South Africa, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, Department of Physiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Department of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Royal Victoria Teaching Hospital, School of Medicine, University of The Gambia, Banjul, The Gambia, Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria, Women's Equity in Access to Care &Treatment, Kigali, Rwanda, HIV-1 Immunopathogenesis Laboratory, Wistar Institute, Philadelphia, PA, Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University, Cleveland, OH, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy, Division of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa, Infectious Diseases Unit, Department of Medicine, Grey's Hospital, Pietermaritzburg, South Africa, Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark, HART (Hypertension in Africa Research Team), North-West University, Potchefstroom, South Africa, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark, Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, South Africa, Department of Medicine, Jos University Teachin
Deepti Gurdasani
Johanna Riha
Kenneth Ekoru
Gershim Asiki
Billy N Mayanja
Naomi S Levitt
Nigel J Crowther
Moffat Nyirenda
Marina Njelekela
Kaushik Ramaiya
Ousman Nyan
Olanisun O Adewole
Kathryn Anastos
Livio Azzoni
W Henry Boom
Caterina Compostella
Joel A Dave
Halima Dawood
Christian Erikstrup
Carla M Fourie
Henrik Friis
Annamarie Kruger
John A Idoko
Chris T Longenecker
Suzanne Mbondi
Japheth E Mukaya
Eugene Mutimura
Chiratidzo E Ndhlovu
George Praygod
Eric W Pefura Yone
Mar Pujades-Rodriguez
Nyagosya Range
Mahmoud U Sani
Aletta E Schutte
Karen Sliwa
Phyllis C Tien
Este H Vorster
Corinna Walsh
Rutendo Zinyama
Fredirick Mashili
Eugene Sobngwi
Clement Adebamowo
Anatoli Kamali
Janet Seeley
Elizabeth H Young
Liam Smeeth
Ayesha A Motala
Pontiano Kaleebu
Manjinder S Sandhu
African Partnership for Chronic Disease Research (APCDR)
University of Cambridge · GBWellcome Sanger Institute · GBMuhimbili University of Health and Allied Sciences · TZUniversity College London · GBUniversity of Cape Town · ZA

Funding

Medical Research Council G0901213Medical Research Council MC_U950080928Medical Research Council MR/K013491/1Wellcome Trust 098504Wellcome Trust 098610Wellcome Trust 100891Wellcome Trust 101113
6 · The paper itself

Abstract

backgroundSub-Saharan Africa (SSA) has the highest burden of HIV in the world and a rising prevalence of cardiometabolic disease; however, the interrelationship between HIV, antiretroviral therapy (ART) and cardiometabolic traits is not well described in SSA populations.

methodsWe conducted a systematic review and meta-analysis through MEDLINE and EMBASE (up to January 2012), as well as direct author contact. Eligible studies provided summary or individual-level data on one or more of the following traits in HIV+ and HIV-, or ART+ and ART- subgroups in SSA: body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TGs) and fasting blood glucose (FBG) or glycated hemoglobin (HbA1c). Information was synthesized under a random-effects model and the primary outcomes were the standardized mean differences (SMD) of the specified traits between subgroups of participants.

resultsData were obtained from 49 published and 3 unpublished studies which reported on 29 755 individuals. HIV infection was associated with higher TGs [SMD, 0.26; 95% confidence interval (CI), 0.08 to 0.44] and lower HDL (SMD, -0.59; 95% CI, -0.86 to -0.31), BMI (SMD, -0.32; 95% CI, -0.45 to -0.18), SBP (SMD, -0.40; 95% CI, -0.55 to -0.25) and DBP (SMD, -0.34; 95% CI, -0.51 to -0.17). Among HIV+ individuals, ART use was associated with higher LDL (SMD, 0.43; 95% CI, 0.14 to 0.72) and HDL (SMD, 0.39; 95% CI, 0.11 to 0.66), and lower HbA1c (SMD, -0.34; 95% CI, -0.62 to -0.06). Fully adjusted estimates from analyses of individual participant data were consistent with meta-analysis of summary estimates for most traits.

conclusionsBroadly consistent with results from populations of European descent, these results suggest differences in cardiometabolic traits between HIV-infected and uninfected individuals in SSA, which might be modified by ART use. In a region with the highest burden of HIV, it will be important to clarify these findings to reliably assess the need for monitoring and managing cardiometabolic risk in HIV-infected populations in SSA.

Indexed as

Africa South of the SaharaAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBody Mass IndexDiabetes MellitusDyslipidemiasHIV InfectionsHumansHypertensionAnti-HIV AgentsARTcardiometabolic diseaseHIVsub-Saharan Africa

Identifiers

PMID24415610
PMCPMC3887568
OpenAlexW2105905549

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.