ArticleAmerican journal of hematology2014
Developmental plasticity of red blood cell homeostasis.
Article in American journal of hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Low-Dose Iron Supplementation in Infancy Modestly Increases Infant Iron Status at 9 Mo without Decreasing Growth or Increasing Illness in a Randomized Clinical Trial in Rural China.The Journal of nutrition · 2016Trial
- Stem Cell and Exosome Therapy in Wound Healing: Traps, Paradoxes, and Tricks Transforming Paradigms.Biomedicines · 2025Article
- Increased Exercise Tolerance in G6PD African Variant Mice Driven by Metabolic Adaptations and Erythrophagocytosis.Antioxidants (Basel, Switzerland) · 2025Article
- Transformer-based artificial intelligence on single-cell clinical data for homeostatic mechanism inference and rational biomarker discovery.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Rapid and reversible optical switching of cell membrane area by an amphiphilic azobenzene.Nature communications · 2023Article
- Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection.JAMA network open · 2020Article
- The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood.Annual review of nutrition · 2019Article
- A cross-sectional survey based on blood VOCs, hematological parameters and urine indicators in a population in Jilin, Northeast China.Environmental geochemistry and health · 2019Article
- Using Hematology Data from Malaria Vaccine Research Trials in Humans and Rhesus Macaques (Comparative medicine · 2016Article
- Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring.Science translational medicine · 2016Article
- Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease.American journal of hematology · 2015Article
- Red blood cell population dynamics.Clinics in laboratory medicine · 2015Review
- Fetal iron deficiency and genotype influence emotionality in infant rhesus monkeys.The Journal of nutrition · 2015Article
- Hereditary xerocytosis revisited.American journal of hematology · 2014Article
- In vivo volume and hemoglobin dynamics of human red blood cells.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Most human physiologic set points like body temperature are tightly regulated and show little variation between healthy individuals. Red blood cell (RBC) characteristics such as hematocrit and mean cell volume are stable within individuals but can vary by 20% from one healthy person to the next. The mechanisms for the majority of this inter-individual variation are unknown and do not appear to involve common genetic variation. Here, we show that environmental conditions present during development, namely in utero iron availability, can exert long-term influence on a set point related to the RBC life cycle. In a controlled study of rhesus monkeys and a retrospective study of humans, we use a mathematical model of in vivo RBC population dynamics to show that in utero iron deficiency is associated with a lowered threshold for RBC clearance and turnover. This in utero effect is plastic, persisting at least 2 years after birth and after the cessation of iron deficiency. Our study reports a rare instance of developmental plasticity in the human hematologic system and also shows how mathematical modeling can be used to identify cellular mechanisms involved in the adaptive control of homeostatic set points.
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