ArticleBlood2014
Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Mapping Therapeutic Regulatory T Cell Fate with MRI: Current Strategies and Translational Outlook.Nanomaterials (Basel, Switzerland) · 2026Review
- The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.The Journal of clinical investigation · 2018Article
- Inhibition of 5-lipoxygenase alleviates graft-versus-host disease.The Journal of experimental medicine · 2017Article
- Viewing immune regulation as it happens: in vivo imaging for investigation of regulatory T-cell function.Immunology and cell biology · 2017Review
- Imaging of anticancer drug action in single cells.Nature reviews. Cancer · 2017Review
- CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.The Journal of clinical investigation · 2017Article
- Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1.Leukemia · 2016Article
- Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.World journal of gastroenterology · 2016Review
- Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems.Current drug targets · 2015Review
- Article
- Intravital multiphoton imaging of cutaneous immune responses.The Journal of investigative dermatology · 2014Article
- Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.Haematologica · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Graft-versus-host disease (GVHD) is a systemic inflammatory response due to the recognition of major histocompatibility complex disparity between donor and recipient after hematopoietic stem cell transplantation (HSCT). T-cell activation is critical to the induction of GVHD, and data from our group and others have shown that regulatory T cells (Tregs) prevent GVHD when given at the time of HSCT. Using multiphoton laser scanning microscopy, we examined the single cell dynamics of donor T cells and dendritic cells (DCs) with or without Tregs postallogeneic transplantation. We found that donor conventional T cells (Tcons) spent very little time screening host DCs. Tcons formed stable contacts with DCs very early after transplantation and only increased velocity in the lymph node at 20 hours after transplant. We also observed that Tregs reduced the interaction time between Tcons and DCs, which was dependent on the generation of interleukin 10 by Tregs. Imaging using inducible Tregs showed similar disruption of Tcon-DC contact. Additionally, we found that donor Tregs induce host DC death and down-regulate surface proteins required for donor T-cell activation. These data indicate that Tregs use multiple mechanisms that affect host DC numbers and function to mitigate acute GVHD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.