ArticleMolecular biology reports2014
C242T polymorphism of NADPH oxidase p22phox gene reduces the risk of coronary artery disease in a random sample of Egyptian population.
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians.Journal of Zhejiang University. Science. B · 2015Pooled it
- Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22International journal of environmental research and public health · 2020Trial
- Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?Journal, genetic engineering & biotechnology · 2021Article
- T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2.International journal of molecular sciences · 2021Article
- AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.Molecular biology reports · 2018Article
- Relationship between C242T polymorphism and arterial stiffness in an apparently healthy population.Journal of human hypertension · 2016Article
- Genetics of coronary artery disease and myocardial infarction.World journal of cardiology · 2016Review
- Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus.Cardiovascular & hematological agents in medicinal chemistry · 2016Review
- Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome.Molecular biology reports · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p22phox protein subunit is essential for NADPH oxidase activity. The prevalence of C242T variants of p22phox gene was studied in 101 healthy Egyptian controls and 104 acute myocardial infarction (AMI) Egyptian patients. Contribution of oxidative stress, represented by serum oxidized-LDL (ox-LDL), in development of AMI was also examined and correlated with C242T gene variants. Genotyping and ox-LDL were assessed by PCR-RFLP and ELISA. Results showed that wild type CC genotype is prevalent in 27 % of controls; CT and TT are in 72 and 1 %. In patients, the distribution was 40.2, 59.8 and 0 % for CC, CT and TT; respectively, showing a significant difference (p = 0.0259). Serum ox-LDL levels were higher in patients than controls (p ≤ 0.0001). Subjects having CT genotype had lower levels of ox-LDL than CC genotype (p ≤ 0.005). C242T polymorphism of p22phox gene of NADPH oxidase is a novel genetic marker associated with reduced susceptibility to AMI.
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