Trial reportPediatric nephrology (Berlin, Germany)2014
Calcium and vitamin D for osteoprotection in children with new-onset nephrotic syndrome treated with steroids: a prospective, randomized, controlled, interventional study.
Trial report in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Interventions for metabolic bone disease in children with chronic kidney disease.The Cochrane database of systematic reviews · 2015Pooled it
- The effect of vitamin D and calcium supplementation in pediatric steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Trial
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- Vitamin D supplementation in children and young adults with persistent proteinuria secondary to glomerular disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Effect of 2-6 weeks of systemic steroids on bone mineral density in children.Clinical and experimental pediatrics · 2022Article
- Dietary intakes of children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Free vitamin D levels in steroid-sensitive nephrotic syndrome and healthy controls.Pediatric nephrology (Berlin, Germany) · 2020Observational
- Bone Health in Glomerular Kidney Disease.Current osteoporosis reports · 2019Review
- Compositional alterations of gut microbiota in children with primary nephrotic syndrome after initial therapy.BMC nephrology · 2019Article
- Vitamin D in incident nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study.Pediatric nephrology (Berlin, Germany) · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are no robust guidelines on strategies to prevent the adverse skeletal effects of glucocorticoids in children.
objectivesTo evaluate the role of prophylactic calcium and vitamin D on bone health in children with new-onset nephrotic syndrome (NS) treated with short-term (12 weeks), high-dose glucocorticoids.
methodsProspective, randomized, controlled, single blind, interventional study conducted on 41 steroid-naïve pre-pubertal children (29 boys, 12 girls). All children received prednisolone for 12 weeks (60 mg/m(2)/day daily for 6 weeks, followed by 40 mg/m(2)/day alternate days for 6 weeks). Recruited children were randomized into the intervention group (IG; vitamin D 1,000 IU/day and elemental calcium 500 mg/day) and the control group (CG). Bone mineral content (BMC) and bone mineral density (BMD) at the lumbar spine (L1-L4) were estimated at baseline and at 12 weeks. Mean percentage changes in BMC and BMD in IG and CG were compared.
resultsChildren in the IG showed an increase of 11.2 % in BMC versus the CG, who showed an 8.9 % fall (p < 0.0001). Net intervention-attributable difference in BMC was 20.1 %. BMD increased in both groups (IG 2.8 % vs CG 0.74 %), but the difference was not statistically significant (p = 0.27).
conclusionsShort-term, high-dose glucocorticoid therapy decreases the BMC of the lumbar spine in steroid-naïve children with NS. Vitamin D and calcium co-administration not only prevents this decline, but also enhances BMC of the lumbar spine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.