SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
The Arg188His polymorphism in the XRCC2 gene and the risk of cancer.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.The Journal of international medical research · 2021Pooled it
- Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer.Oncotarget · 2016Pooled it
- An association between the -41657 C/T polymorphism of X-ray repair cross-complementing 2 (XRCC2) gene and ovarian cancer.Medical oncology (Northwood, London, England) · 2014Trial
- XRCC2 gene polymorphisms and its protein are associated with colorectal cancer susceptibility in Chinese Han population.Medical oncology (Northwood, London, England) · 2014Trial
- Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.Molecular biology reports · 2021Article
- Analysis of the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk.Archives of medical science : AMS · 2020Article
- Polymorphism of DNA Repair Genes via Homologous Recombination (HR) in Ovarian Cancer.Pathology oncology research : POR · 2019Article
- Polymorphism of DNA repair genes in breast cancer.Oncotarget · 2019Article
- Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer.Scientific reports · 2017Article
- MiRNA-binding site functional polymorphisms in DNA repair genes RAD51, RAD52, and XRCC2 and breast cancer risk in Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Analysis ofBiomedical reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arg188His polymorphism in the XRCC2 gene has been suggested as a risk factor for cancer with inconclusive results. The aim of the current study is to investigate the association between the polymorphism with of cancer by meta-analysis. A total of 33 case-control studies from 27 publications were included for data analyses. The results suggested that the Arg188His polymorphism was not associated with increased/decreased risk of cancer in total analysis (Arg/His+His/His vs. Arg/Arg: OR = 0.98, 95% CI = 0.91-1.06). In the subgroup analysis by ethnicity, no statistical significant association was found in Europeans. In the subgroup analysis by cancer types, statistical significant association was found in ovarian cancer but not in other cancers. The current meta-analysis indicated that the Arg188His polymorphism in the XRCC2 gene might be a risk factor for ovarian cancer. In the future, more large-scale case-control studies are needed to validate our results.
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