ArticleAmerican journal of physiology. Heart and circulatory physiology2014
Skeletal muscle microvascular oxygenation dynamics in heart failure: exercise training and nitric oxide-mediated function.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Physiological Mechanisms Driving Microcirculatory Enhancement: the Impact of Physical Activity.Reviews in cardiovascular medicine · 2025Pooled it
- Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy.Experimental physiology · 2026Article
- Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.Nitric oxide : biology and chemistry · 2022Article
- Animal exercise studies in cardiovascular research: Current knowledge and optimal design-A position paper of the Committee on Cardiac Rehabilitation, Chinese Medical Doctors' Association.Journal of sport and health science · 2021Article
- Effects of Acute Microcurrent Electrical Stimulation on Muscle Function and Subsequent Recovery Strategy.International journal of environmental research and public health · 2021Article
- The role of vascular function on exercise capacity in health and disease.The Journal of physiology · 2021Review
- Transcapillary POThe Journal of physiology · 2020Article
- Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model.Acta diabetologica · 2020Article
- Guidelines for animal exercise and training protocols for cardiovascular studies.American journal of physiology. Heart and circulatory physiology · 2020Review
- Netrin-1 plays a role in the effect of moderate exercise on myocardial fibrosis in rats.PloS one · 2019Article
- Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure.Nitric oxide : biology and chemistry · 2018Article
- Exercise limitations in heart failure with reduced and preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- A practical approach to assess leg muscle oxygenation during ramp-incremental cycle ergometry in heart failure.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Vascular KRespiratory physiology & neurobiology · 2017Article
- Dietary nitrate supplementation: impact on skeletal muscle vascular control in exercising rats with chronic heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Review
- Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization.American journal of physiology. Heart and circulatory physiology · 2015Review
- Emerging risk biomarkers in cardiovascular diseases and disorders.Journal of lipids · 2015Review
- Physical exercise associated with NO production: signaling pathways and significance in health and disease.Frontiers in cell and developmental biology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic heart failure (CHF) impairs nitric oxide (NO)-mediated regulation of skeletal muscle O2 delivery-utilization matching such that microvascular oxygenation falls faster (i.e., speeds PO2mv kinetics) during increases in metabolic demand. Conversely, exercise training improves (slows) muscle PO2mv kinetics following contractions onset in healthy young individuals via NO-dependent mechanisms. We tested the hypothesis that exercise training would improve contracting muscle microvascular oxygenation in CHF rats partly via improved NO-mediated function. CHF rats (left ventricular end-diastolic pressure = 17 ± 2 mmHg) were assigned to sedentary (n = 11) or progressive treadmill exercise training (n = 11; 5 days/wk, 6-8 wk, final workload of 60 min/day at 35 m/min; -14% grade downhill running) groups. PO2mv was measured via phosphorescence quenching in the spinotrapezius muscle at rest and during 1-Hz twitch contractions under control (Krebs-Henseleit solution), sodium nitroprusside (SNP; NO donor; 300 μM), and N(G)-nitro-l-arginine methyl ester (L-NAME, nonspecific NO synthase blockade; 1.5 mM) superfusion conditions. Exercise-trained CHF rats had greater peak oxygen uptake and spinotrapezius muscle citrate synthase activity than their sedentary counterparts (p < 0.05 for both). The overall speed of the PO2mv fall during contractions (mean response time; MRT) was slowed markedly in trained compared with sedentary CHF rats (sedentary: 20.8 ± 1.4, trained: 32.3 ± 3.0 s; p < 0.05), and the effect was not abolished by L-NAME (sedentary: 16.8 ± 1.5, trained: 31.0 ± 3.4 s; p > 0.05). Relative to control, SNP increased MRT in both groups such that trained CHF rats had slower kinetics (sedentary: 43.0 ± 6.8, trained: 55.5 ± 7.8 s; p < 0.05). Improved NO-mediated function is not obligatory for training-induced improvements in skeletal muscle microvascular oxygenation (slowed PO2mv kinetics) following contractions onset in rats with CHF.
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Registered trials
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