ArticleProceedings of the National Academy of Sciences of the United States of America1987
Differential expression of opioid peptide genes by testicular germ cells and somatic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harbor perspectives in medicine · 2021Review
- Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia.Theranostics · 2021Article
- Adenylation by testis-specific cytoplasmic poly(A) polymerase, PAPOLB/TPAP, is essential for spermatogenesis.The Journal of reproduction and development · 2016Article
- Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.The Journal of reproduction and development · 2016Article
- Regulation of male fertility by the opioid system.Molecular medicine (Cambridge, Mass.) · 2011Review
- Interleukin-6 regulation of kappa opioid receptor gene expression in primary sertoli cells.Endocrine · 2000Article
- Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.The Biochemical journal · 2000Article
- Modulation of preoptic regulatory factor-2 (porf-2) mRNAs by castration and hypophysectomy.Endocrine · 1997Article
- The transcriptional regulation of the preproenkephalin gene.The Biochemical journal · 1995Review
- Atypical prodynorphin gene expression in corticosteroid-producing cells of the rat adrenal gland.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- List of cloned mouse genes with unique expression patterns during spermatogenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Proenkephalin products are stored in the sperm acrosome and may function in fertilization.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Pituitary-like proopiomelanocortin transcripts in human Leydig cell tumors.The Journal of clinical investigation · 1990Article
- Transcription of the rat and mouse proenkephalin genes is initiated at distinct sites in spermatogenic and somatic cells.Molecular and cellular biology · 1990Article
- The regulation of proenkephalin expression in a distinct population of glial cells.The EMBO journal · 1990Article
- Regulated expression of proenkephalin A during ontogenic development of mesenchymal derivative tissues.Molecular and cellular biology · 1990Article
- Proenkephalin A is expressed in mesodermal lineages during organogenesis.The EMBO journal · 1989Article
- Translational control of germ cell-expressed mRNA imposed by alternative splicing: opioid peptide gene expression in rat testis.Molecular and cellular biology · 1989Article
- Transient expression of the cholecystokinin gene in male germ cells and accumulation of the peptide in the acrosomal granule: possible role of cholecystokinin in fertilization.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
Corrections and comments
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3 authors.
Funding
Abstract
Spermatogenic cells have been previously shown to be a major site of testicular proenkephalin gene expression. Using RNA gel-blot analysis of purified mouse and hamster germ cells and of testes from prepuberal and germ cell-deficient mutant mice, we now have demonstrated that, in addition to its previously described expression by somatic (Leydig) cells, the gene for a second opioid peptide precursor, pro-opiomelanocortin (POMC), is also expressed by spermatogenic cells. Of particular significance is the finding that the RNAs for proenkephalin and POMC are differentially regulated during spermatogenesis. Two forms of POMC RNA were detected in mouse testis, a larger component 675- to 750-nucleotides (nt) in size common to somatic and spermatogenic cells and a smaller 625-nt RNA found only in pachytene spermatocytes. Two distinct, cell-specific proenkephalin RNAs were also shown to be present in mouse testis: a 1700-nt transcript previously shown to be expressed by spermatogenic cells and a 1450-nt form associated with somatic cells. These data suggest that proenkephalin- and POMC-derived peptides are produced by both somatic cells and germ cells in the testis and in germ cells these two families of opioid peptides may function at different stages of spermatogenesis.
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