ReviewPlant cell reports2014
Transgenic approach to increase artemisinin content in Artemisia annua L.
Review in Plant cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 98 citations in OpenAlex.
- Metabolic engineering inaBIOTECH · 2025Review
- Safeguarding artemisinin: integrating bioproduction innovation and resistance management for malaria eradication.Malaria journal · 2025Review
- Unlocking the potential of3 Biotech · 2025Review
- A transcription factor of SHI family AaSHI1 activates artemisinin biosynthesis genes in Artemisia annua.BMC genomics · 2024Article
- TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua.Molecular horticulture · 2024Article
- The Light- and Jasmonic Acid-InducedInternational journal of molecular sciences · 2023Article
- Bioproduction of monoterpene indole alkaloids in a single cell factory.Engineering microbiology · 2022Article
- Plants as Sources of Natural and Recombinant Antimalaria Agents.Molecular biotechnology · 2022Review
- From Plant to Yeast-Advances in Biosynthesis of Artemisinin.Molecules (Basel, Switzerland) · 2022Review
- Impact of Phosphatic Nutrition on Growth Parameters and Artemisinin Production inLife (Basel, Switzerland) · 2022Article
- Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand.Frontiers in plant science · 2022Review
- Towards greenhouse cultivation ofFrontiers in plant science · 2022Article
- Worldwide Research Trends on Artemisinin: A Bibliometric Analysis From 2000 to 2021.Frontiers in medicine · 2022Article
- Review
- Identification and the potential involvement of miRNAs in the regulation of artemisinin biosynthesis in A. annua.Scientific reports · 2020Article
- AaABCG40 Enhances Artemisinin Content and Modulates Drought Tolerance inFrontiers in plant science · 2020Article
- Interaction of bZIP transcription factor TGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua.Journal of experimental botany · 2019Article
- Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps.Plants (Basel, Switzerland) · 2019Review
- The Recruitment Model of Metabolic Evolution: Jasmonate-Responsive Transcription Factors and a Conceptual Model for the Evolution of Metabolic Pathways.Frontiers in plant science · 2019Review
- Biotechnological approaches for artemisinin production in Artemisia.World journal of microbiology & biotechnology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisinin, the endoperoxide sesquiterpene lactone, is an effective antimalarial drug isolated from the Chinese medicinal plant Artemisia annua L. Due to its effectiveness against multi-drug-resistant cerebral malaria, it becomes the essential components of the artemisinin-based combination therapies which are recommended by the World Health Organization as the preferred choice for malaria tropica treatments. To date, plant A. annua is still the main commercial source of artemisinin. Although semi-synthesis of artemisinin via artemisinic acid in yeast is feasible at present, another promising approach to reduce the price of artemisinin is using plant metabolic engineering to obtain a higher content of artemisinin in transgenic plants. In the past years, an Agrobacterium-mediated transformation system of A. annua has been established by which a number of genes related to artemisinin biosynthesis have been successfully transferred into A. annua plants. In this review, the progress on increasing artemisinin content in A. annua by transgenic approach and its future prospect are summarized and discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.