ArticleScientific reports2014
Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- Machine learning implementation strategy in imaging and impedance flow cytometry.Biomicrofluidics · 2023Review
- Morphological profiling by high-throughput single-cell biophysical fractometry.Communications biology · 2023Article
- High-speed laser-scanning biological microscopy using FACED.Nature protocols · 2021Article
- Deep tissue space-gated microscopy via acousto-optic interaction.Nature communications · 2020Article
- A practical guide to intelligent image-activated cell sorting.Nature protocols · 2019Article
- Multi-ATOM: Ultrahigh-throughput single-cell quantitative phase imaging with subcellular resolution.Journal of biophotonics · 2019Article
- High-throughput label-free flow cytometry based on matched-filter compressive imaging.Biomedical optics express · 2018Article
- High-throughput imaging flow cytometry by optofluidic time-stretch microscopy.Nature protocols · 2018Article
- Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM).Journal of visualized experiments : JoVE · 2017Article
- All-passive pixel super-resolution of time-stretch imaging.Scientific reports · 2017Article
- Time-stretch microscopy on a DVD for high-throughput imaging cell-based assay.Biomedical optics express · 2017Article
- Ultrafast laser-scanning time-stretch imaging at visible wavelengths.Light, science & applications · 2017Article
- Ultrafast time-stretch imaging at 932 nm through a new highly-dispersive fiber.Biomedical optics express · 2016Article
- Ultrafast measurements of optical spectral coherence by single-shot time-stretch interferometry.Scientific reports · 2016Article
- High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch.Biomedical optics express · 2015Article
- Optical data compression in time stretch imaging.PloS one · 2015Article
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13 authors.
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Abstract
Accelerating imaging speed in optical microscopy is often realized at the expense of image contrast, image resolution, and detection sensitivity--a common predicament for advancing high-speed and high-throughput cellular imaging. We here demonstrate a new imaging approach, called asymmetric-detection time-stretch optical microscopy (ATOM), which can deliver ultrafast label-free high-contrast flow imaging with well delineated cellular morphological resolution and in-line optical image amplification to overcome the compromised imaging sensitivity at high speed. We show that ATOM can separately reveal the enhanced phase-gradient and absorption contrast in microfluidic live-cell imaging at a flow speed as high as ~10 m/s, corresponding to an imaging throughput of ~100,000 cells/sec. ATOM could thus be the enabling platform to meet the pressing need for intercalating optical microscopy in cellular assay, e.g. imaging flow cytometry--permitting high-throughput access to the morphological information of the individual cells simultaneously with a multitude of parameters obtained in the standard assay.
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