ReviewAmerican journal of Alzheimer's disease and other dementias2014
Possible link between Toxoplasma gondii and the anosmia associated with neurodegenerative diseases.
Review in American journal of Alzheimer's disease and other dementias, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Neuroinflammation in Alzheimer's Disease: A Potential Role of Nose-Picking in Pathogen Entry via the Olfactory System?Biomolecules · 2023Review
- Global seroprevalence ofHealth science reports · 2023Article
- Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions.Translational research : the journal of laboratory and clinical medicine · 2020Review
- The Viral Hypothesis in Alzheimer's Disease: Novel Insights and Pathogen-Based Biomarkers.Journal of personalized medicine · 2020Review
- Article
- Development of an in vitro system to study the developmental stages of Toxoplasma gondii using a genetically modified strain expressing markers for tachyzoites and bradyzoites.Parasitology research · 2019Article
- The Possibility of an Infectious Etiology of Alzheimer Disease.Molecular neurobiology · 2019Review
- Review
- The intestinal microbiome and Alzheimer's disease: A review.Animal models and experimental medicine · 2018Review
- Review
- Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.Scientific reports · 2017Article
- Interactions between the microbiota, immune and nervous systems in health and disease.Nature neuroscience · 2017Review
- Reexamining ChronicCurrent clinical microbiology reports · 2016Article
- Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls.Microbes and infection · 2016Article
- Biotic/Abiotic Stress-Driven Alzheimer's Disease.Frontiers in cellular neuroscience · 2016Article
- 3-D imaging and analysis of neurons infected in vivo with Toxoplasma gondii.Journal of visualized experiments : JoVE · 2014Article
- Midichlorians--the biomeme hypothesis: is there a microbial component to religious rituals?Biology direct · 2014Article
- Pathogenic microbes, the microbiome, and Alzheimer's disease (AD).Frontiers in aging neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxoplasma gondii is an intracellular protozoan infecting 30% to 50% of global human population. Recently, it was suggested that chronic latent neuroinflammation caused by the parasite may be responsible for the development of several neurodegenerative diseases manifesting with the loss of smell. Studies in animals inoculated with the parasite revealed cysts in various regions of the brain, including olfactory bulb. Development of behavioral changes was paralleled by the preferential persistence of cysts in defined anatomic structures of the brain, depending on the host, strain of the parasite, its virulence, and route of inoculation. Olfactory dysfunction reported in Alzheimer's disease, multiple sclerosis, and schizophrenia was frequently associated with the significantly increased serum anti-T gondii immunoglobulin G antibody levels. Damage of the olfactory system may be also at least in part responsible for the development of depression because T gondii infection worsened mood in such patients, and the olfactory bulbectomized rat serves as a model of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.