Evidence map›Paper›PMID 24413353›Full record

ArticleBMJ open2014

Systematic analysis of funding awarded for mycology research to institutions in the UK, 1997-2010.

Michael G Head, Joseph R Fitchett, Rifat Atun, Robin C May

Abstract read
In one paragraph

Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Biosensors and Diagnostics for Fungal Detection.Journal of fungi (Basel, Switzerland) · 2020
    Review
  8. Review
  9. Targeting a critical step in fungal hexosamine biosynthesis.The Journal of biological chemistry · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Tackling emerging fungal threats to animal health, food security and ecosystem resilience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael G HeadResearch Department of Infection and Population Health, University College London, London, UK.
Joseph R Fitchett
Rifat Atun
Robin C May

Funding

Medical Research Council MR/J008176/1Medical Research Council MR/K006584/1Wellcome Trust
6 · The paper itself

Abstract

objectivesFungal infections cause significant global morbidity and mortality. We have previously described the UK investments in global infectious disease research, and here our objective is to describe the investments awarded to UK institutions for mycology research and outline potential funding gaps in the UK portfolio.

designSystematic analysis.

settingUK institutions carrying out infectious disease research. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome is the amount of funding and number of studies related to mycology research. Secondary outcomes are describing the investments made to specific fungal pathogens and diseases, and also the type of science along the R&D value chain.

methodsWe systematically searched databases and websites for information on research studies from public and philanthropic funding institutions awarded between 1997 and 2010, and highlighted the mycology-related projects.

resultsOf 6165 funded studies, we identified 171 studies related to mycology (total investment £48.4 million, 1.9% of all infection research, with mean annual funding £3.5 million). Studies related to global health represented 5.1% of this funding (£2.4 million, compared with 35.6% of all infectious diseases). Leading funders were the Biotechnology and Biological Sciences Research Council (£14.8 million, 30.5%) and Wellcome Trust (£12.0 million, 24.7%). Preclinical studies received £42.2 million (87.3%), with clinical trials, intervention studies and implementation research in total receiving £6.2 million (12.7%). By institution, University of Aberdeen received most funding (£16.9 million, 35%). Studies investigating antifungal resistance received £1.5 million (3.2%).

conclusionsThere is little translation of preclinical research into clinical trials or implementation research in spite of substantial disease burden globally, and there are few UK institutions that carry out significant quantities of mycology research of any type. In the context of global health and the burden of disease in low-income countries, more investment is required for mycology research.

Indexed as

MycosesResearch Support as TopicBiomedical ResearchHumansMycologyTime FactorsUnited KingdomBASIC SCIENCESINFECTIOUS DISEASESMYCOLOGY

Identifiers

PMID24413353
PMCPMC3902376

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.